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1-Boc-4-methanesulfonyloxypiperidine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 141699-59-4 Structure
  • Basic information

    1. Product Name: 1-Boc-4-methanesulfonyloxypiperidine
    2. Synonyms: N-(TERT-BUTOXYCARBONYL)PIPERIDIN-4-YL MESYLATE;N-BOC-4-(methanesulfonyloxy)piperidine;1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate;1-Boc-methanesulfonyl-piperdine;4-[(Methylsulphonyl)oxy]piperidine, N-BOC protected;tert-Butyl 4-[(methylsulphonyl)oxy]piperidine-1-carboxylate;1-Piperidinecarboxylicacid,4-[(Methylsulfonyl)oxy]-,1,1-diMethylethylester;4-Methanesulfonyloxypiperidin-1-carboxylic acid tert-butyl ester
    3. CAS NO:141699-59-4
    4. Molecular Formula: C11H21NO5S
    5. Molecular Weight: 279.35
    6. EINECS: 200-081-4
    7. Product Categories: pharmacetical
    8. Mol File: 141699-59-4.mol
  • Chemical Properties

    1. Melting Point: 193-195 °C
    2. Boiling Point: 407.186 °C at 760 mmHg
    3. Flash Point: 200.059 °C
    4. Appearance: /
    5. Density: 1.223 g/cm3
    6. Vapor Pressure: 7.69E-07mmHg at 25°C
    7. Refractive Index: 1.5
    8. Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. PKA: -3.02±0.40(Predicted)
    11. CAS DataBase Reference: 1-Boc-4-methanesulfonyloxypiperidine(CAS DataBase Reference)
    12. NIST Chemistry Reference: 1-Boc-4-methanesulfonyloxypiperidine(141699-59-4)
    13. EPA Substance Registry System: 1-Boc-4-methanesulfonyloxypiperidine(141699-59-4)
  • Safety Data

    1. Hazard Codes: T
    2. Statements: 25-20/21/22
    3. Safety Statements: 45-24/25-23
    4. RIDADR: 2811
    5. WGK Germany:
    6. RTECS:
    7. HazardClass: 6.1
    8. PackingGroup:
    9. Hazardous Substances Data: 141699-59-4(Hazardous Substances Data)

141699-59-4 Usage

Chemical Properties

White powder

Check Digit Verification of cas no

The CAS Registry Mumber 141699-59-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,6,9 and 9 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 141699-59:
(8*1)+(7*4)+(6*1)+(5*6)+(4*9)+(3*9)+(2*5)+(1*9)=154
154 % 10 = 4
So 141699-59-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H21NO5S/c1-11(2,3)16-10(13)12-7-5-9(6-8-12)17-18(4,14)15/h9H,5-8H2,1-4H3

141699-59-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-Boc-4-Methanesulfonyloxypiperidine

1.2 Other means of identification

Product number -
Other names 4-(Methanesulfonyloxy)piperidine-1-carboxylic Acid tert-Butyl Ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:141699-59-4 SDS

141699-59-4Relevant articles and documents

SUBSTITUTED AMINOQUINOLONES AS DGKALPHA INHIBITORS FOR IMMUNE ACTIVATION

-

Page/Page column 129-130, (2021/06/04)

The present invention covers aminoquinolone compounds of general formula (I) : in which R1, R2, R3, R4, R5, R6, R7, R8, X and n are as defined herein, methods of prepa

Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis

Klug, Dana M.,Mavrogiannaki, Eftychia M.,Forbes, Katherine C.,Silva, Lisseth,Diaz-Gonzalez, Rosario,Pérez-Moreno, Guiomar,Ceballos-Pérez, Gloria,Garcia-Hernández, Raquel,Bosch-Navarrete, Cristina,Cordón-Obras, Carlos,Gómez-Li?án, Claudia,Saura, Andreu,Momper, Jeremiah D.,Martinez-Martinez, Maria Santos,Manzano, Pilar,Syed, Ali,El-Sakkary, Nelly,Caffrey, Conor R.,Gamarro, Francisco,Ruiz-Perez, Luis Miguel,Gonzalez Pacanowska, Dolores,Ferrins, Lori,Navarro, Miguel,Pollastri, Michael P.

supporting information, p. 9404 - 9430 (2021/07/25)

Neglected tropical diseases such as human African trypanosomiasis (HAT) are prevalent primarily in tropical climates and among populations living in poverty. Historically, the lack of economic incentive to develop new treatments for these diseases has meant that existing therapeutics have serious shortcomings in terms of safety, efficacy, and administration, and better therapeutics are needed. We now report a series of 3,5-disubstituted-7-azaindoles identified as growth inhibitors of Trypanosoma brucei, the parasite that causes HAT, through a high-throughput screen. We describe the hit-to-lead optimization of this series and the development and preclinical investigation of 29d, a potent antitrypanosomal compound with promising pharmacokinetic (PK) parameters. This compound was ultimately not progressed beyond in vivo PK studies due to its inability to penetrate the blood-brain barrier (BBB), critical for stage 2 HAT treatments.

Synthesis and Characterization of N-(4-(Piperidin-4-ylsulfonyl) phenyl)5-vinylpyrimidin-2-amine

Dong, Jingjing,Feng, Baicheng,Jin, Yan,Lu, Jianqiang,Wang, Tielin

, p. 255 - 258 (2021/08/05)

Target product N-(4-(piperidin-4-ylsulfonyl)phenyl)5-vinylpyrimidin-2- amine (13) was synthesized using 6-oxopyran-3-carbaldehyde (M1) and 4-hydroxypiperidine (M2) as starting materials by a series of nucleophilic substitution and oxidation. Different aci

CXCR2 ANTAGONIST

-

Paragraph 0097-0099; 0122-0124, (2020/11/23)

A compound as a CXCR2 antagonist and an application thereof in preparing a drug as a CXCR2 antagonist. In particular, the present invention relates to a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof.

Copper-Catalyzed Cross-Coupling between Alkyl (Pseudo)halides and Bicyclopentyl Grignard Reagents

Andersen, Claire,Bernardelli, Patrick,Cossy, Janine,Daumas, Marc,Ferey, Vincent,Guérinot, Amandine

, (2020/08/05)

The development of a copper-catalyzed cross-coupling between primary and secondary (pseudo)halides and bicyclopentyl Grignard reagents is reported. Highly strained bicyclopentanes can be cross-coupled with a large panel of primary alkyl mesylates and secondary alkyl iodides. The catalytic system is simple and cheap, and the reaction is general and chemoselective.

PYRROLO(PYRAZOLO)PYRIMIDINE DERIVATIVE AS LRRK2 INHIBITOR

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Paragraph 0119-0120, (2020/11/23)

The present invention relates to a pyrrolo(pyrazolo)pyrimidine derivative having efficacy as an LRRK2 inhibitor, a preparation method therefor, and a pharmaceutical composition for preventing or treating degenerative brain diseases, containing the same.

1, 2, 4-OXADIAZOLE DERIVATIVES AND USES THEREOF

-

Paragraph 0094, (2020/04/25)

The disclosure provides 1, 2, 4-oxadiazole derivatives useful for stemming bleeding and for treating cancer.

1, 3, 4-OXADIAZOLE DERIVATIVES AND USES THEREOF

-

Paragraph 0082, (2020/04/25)

The disclosure provides 1, 3, 4-oxadiazole derivatives useful for stemming bleeding and for treating cancer.

IRAK DEGRADERS AND USES THEREOF

-

Paragraph 00962; 002942-002944, (2020/06/19)

The present invention provides compounds, compositions thereof, and methods of using the same.

Pyrrolo[2, 3-d] pyrimidine derivatives containing piperidine as well as preparation and application thereof

-

Paragraph 0121; 0124; 0125, (2020/09/16)

The invention relates to a piperidine-containing pyrrolo[2, 3-d] pyrimidine derivative as shown in a general formula I or a general formula II as well as a use method and a preparation method thereof.The invention also relates to a strong JAK kinase inhibition effect of the compound shown in the general formula I or II, the invention also relates to an application of the compound in preparation of medicines for treating and/or preventing diseases caused by abnormal expression of JAK, and particularly relates to application of the compound in preparation of medicines for treating inflammatory/autoimmune diseases, fibrosis and cancers.

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