Synthesis and Antiarrhythmic Activity of cis-2,6-Dimethyl-α,α-diaryl-1-piperidinebutanols
A series of α,α-diaryl-1-piperidinebutanols was evaluated for antiarrhythmic activity in the coronary ligated dog model.Structure-activity relationship studies indicated that the 2,6-dimethylpiperidine group yielded compounds with the best antiarrhythmic
Hoefle, M. L.,Blouin, L. T.,Fleming, R. W.,Hastings, S.,Hinkley, J. M.,et al.
p. 12 - 19
(2007/10/02)
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