130403-05-3Relevant articles and documents
New N-aryl isoxazolecarboxamides and N-isoxazolylbenzamides as anticonvulsant agents
Lepage,Tombret,Cuvier,Marivain,Gillardin
, p. 581 - 593 (2007/10/02)
We prepared a series of N-aryl isoxazolecarboxamide, N-isoxazolylbenzamide compounds and derivatives and studied their anticonvulsant action in MES and MMS tests. Some of these reveal considerable activity, especially with respect to MES test. The disubstitution in the 2.6-position on the phenyl ring by two methyl groups would appear to be of primary importance for the activity. The amide bridge between the phenyl and isoxazolic rings, whether of the anilide or benzamide type, seems to show similar anticonvulsant behavior. We have selected the derivatives 8 (N-(2.6-dimethylphenyl)-5-methyl-3-isoxazolecarboxamide, 12 (N-(2.6-dimethylphenyl)-5-hydroxymethyl-3-isoxazolecarboxamide) and 51 (N-(5-methyl-3-isoxazolyl)-2.6-dimethylbenzamide) which are presently being studied in more extended pharmacological tests.
Novel isoxazole and isoxazoline compounds with anticonvulsant activity process for their preparation and therapeutic composition containing them
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, (2008/06/13)
The object of the invention are anticonvulsant heterocyclic compounds of general formula: STR1 in which R1 and R2 is each selected from C1 -C4 alkyl, phenyl, benzyl, trifluoromethyl or halogen, R3 is