- FLOW CHEMISTRY SYNTHESIS OF ISOCYANATES
-
The disclosure provides, inter alia, safe and environmentally-friendly methods, such as flow chemistry, to synthesize isocyanates, such as methylene diphenyl diisocyanate, toluene diisocyanate, hexamethylene diisocyanate, isophorone diisocyanate, and tetramethylxylene diisocyanate.
- -
-
Paragraph 0175; 0186-0187; 0217-0218; 0220-0221
(2021/06/22)
-
- A toolbox for controlling the properties and functionalisation of hydrazone-based supramolecular hydrogels
-
In recent years, we have developed a low molecular weight hydrogelator system that is formed in situ under ambient conditions through catalysed hydrazone formation between two individually non-gelating components. In this contribution, we describe a molecular toolbox based on this system which allows us to (1) investigate the limits of gel formation and fine-tuning of their bulk properties, (2) introduce multicolour fluorescent probes in an easy fashion to enable high-resolution imaging, and (3) chemically modify the supramolecular gel fibres through click and non-covalent chemistry, to expand the functionality of the resultant materials. In this paper we show preliminary applications of this toolbox, enabling covalent and non-covalent functionalisation of the gel network with proteins and multicolour imaging of hydrogel networks with embedded mammalian cells and their substructures. Overall, the results show that the toolbox allows for on demand gel network visualisation and functionalisation, enabling a wealth of applications in the areas of chemical biology and smart materials.
- Poolman, Jos M.,Maity, Chandan,Boekhoven, Job,Van Der Mee, Lars,Le Sage, Vincent A.A.,Groenewold, G.J. Mirjam,Van Kasteren, Sander I.,Versluis, Frank,Van Esch, Jan H.,Eelkema, Rienk
-
supporting information
p. 852 - 858
(2016/02/05)
-
- Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments
-
Novel products of formula (I), their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments. In the formula (I), the following substituents are among the preferred: Ar represents a substituted or co
- -
-
-
- Ring Opening of 2-Oxocyclohexane Carboxamide to 2-Hydroximinopimelic-1-amide
-
Reaction of 2-oxocyclohexane carboxamide (1) and sodium nitrite in 1 n hydrochloric acid yields 2-hydroximinopimelic-1-amide (2). 2 and dimethylsulphate react to give compounds 3 and 4, respectively, 2 and 1,6-diamino hexane form salt 5, 2 and cyclohexanone (resp. cyclopentanone) yield imidazoline-N-oxide 6 (and 7, resp.) 2 and hydrazine afford pimelic hydrazide (8).
- Bischoff, Christian,Schroeder, Edith
-
p. 379 - 382
(2007/10/02)
-
