- Process for the preparation of α-fluoroacryloyl derivatives
-
α-Fluoroacryloyl derivatives are prepared by reacting a dihalogenopropene with an anhydrous mixture of nitric acid and hydrofluoric acid to give a 1-nitro-2,2-fluorohalogeno-3-halogenopropane, converting this in the presence of a strong acid and a little water at elevated temperature to a 2,2-fluorohalogeno-3-halogenopropanoic acid, converting this into an ester or an amide and finally treating this with a dehalogenating agent.
- -
-
-
- Synthese von α-Fluoracrylsaeure und Derivaten
-
Three new routes to derivatives of α-fluoracrylic acid, including a laboratory synthesis and a large-scale method, are reported.The processes are (i) addition of elementary fluorine to acrylic esters and subsequent elimination of HF; (ii) addition of difluorocarbene to isopropenyl methyl ether, oxidation via ring opening and dehalogenation; and (iii) "nitrofluorination" of 2,3-dichloropropene, hydrolysis and dechlorination.
- Gassen, K.-R.,Bielefeldt, D.,Marhold, A.,Andres P.
-
p. 149 - 162
(2007/10/02)
-