13071-88-0Relevant academic research and scientific papers
Process for the preparation of α-fluoroacryloyl derivatives
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, (2008/06/13)
α-Fluoroacryloyl derivatives are prepared by reacting a dihalogenopropene with an anhydrous mixture of nitric acid and hydrofluoric acid to give a 1-nitro-2,2-fluorohalogeno-3-halogenopropane, converting this in the presence of a strong acid and a little water at elevated temperature to a 2,2-fluorohalogeno-3-halogenopropanoic acid, converting this into an ester or an amide and finally treating this with a dehalogenating agent.
Synthese von α-Fluoracrylsaeure und Derivaten
Gassen, K.-R.,Bielefeldt, D.,Marhold, A.,Andres P.
, p. 149 - 162 (2007/10/02)
Three new routes to derivatives of α-fluoracrylic acid, including a laboratory synthesis and a large-scale method, are reported.The processes are (i) addition of elementary fluorine to acrylic esters and subsequent elimination of HF; (ii) addition of difluorocarbene to isopropenyl methyl ether, oxidation via ring opening and dehalogenation; and (iii) "nitrofluorination" of 2,3-dichloropropene, hydrolysis and dechlorination.
