- An organocatalytic asymmetric allylic alkylation allows enantioselective total synthesis of hydroxymetasequirin-a and metasequirin-b tetramethyl ether diacetates
-
The first highly stereoselective organocatalytic intermolecular allylic alkylation of allylic alcohols with 1,3-dicarbonyls has been developed to allow the first enantioselective total synthesis of hydroxymetasequirin-A and metasequirin-B tetramethyl ethe
- Wang, Pu-Sheng,Zhou, Xiao-Le,Gong, Liu-Zhu
-
supporting information
p. 976 - 979
(2014/03/21)
-
- Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors
-
Based on classical colchicine site ligands and a computational model of the colchicine binding site on beta tubulin, two classes of chalcone derivatives were designed, synthesized and evaluated for inhibition of tubulin assembly and toxicity in human canc
- Salum, Lívia B.,Altei, Wanessa F.,Chiaradia, Louise D.,Cordeiro, Marlon N.S.,Canevarolo, Rafael R.,Melo, Carolina P.S.,Winter, Evelyn,Mattei, Bruno,Daghestani, Hikmat N.,Santos-Silva, Maria Cláudia,Creczynski-Pasa, Tania B.,Yunes, Rosendo A.,Yunes, José A.,Andricopulo, Adriano D.,Day, Billy W.,Nunes, Ricardo J.,Vogt, Andreas
-
supporting information
p. 501 - 510
(2013/07/25)
-
- NBS-mediated cyclization of trans-cinnamic alcohols
-
An efficient and straightforward three-step synthetic route toward 2,4-disubstituted-3-bromooxetanes 5 with the trans-trans contiguous stereogenic centers is developed from functionalized chalcones 3 via NaBH 4-mediated reduction of chalcones 3
- Chang, Meng-Yang,Tsai, Chung-Yu,Wu, Ming-Hao
-
p. 6364 - 6370
(2013/07/26)
-
- Synthesis and biological evaluation of 3′,4′,5′-trimethoxychalcone analogues as inhibitors of nitric oxide production and tumor cell proliferation
-
A series of 23 3′,4′,5′-trimethoxychalcone analogues was synthesized and their inhibitory effects on nitric oxide (NO) production in LPS/IFN-γ-treated macrophages, and tumor cell proliferation has been investigated. 4-Hydroxy-3,3′,4′,5′-tetramethoxychalco
- Rao, Yerra Koteswara,Fang, Shih-Hua,Tzeng, Yew-Min
-
experimental part
p. 7909 - 7914
(2010/03/25)
-
- Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents
-
A series of substituted chalcones and their corresponding pyrazoles were synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 93 compounds screened, 8 compounds, 1s, 3i,j,n, 4i,j,n and 4s, showed marked activity. Compounds 4j,n and 4s were found to be the most promising in this study. SAR is also discussed.
- Bhat,Dhar,Puri,Saxena,Shanmugavel,Qazi
-
p. 3177 - 3180
(2007/10/03)
-
- Synthesis and anti-inflammatory activity of chalcone derivatives
-
Chalcones and their derivatives were synthesized and evaluated for their anti-inflammatory activity. In vitro, chalcones 2, 4, 8, 10 and 13 inhibited degranulation and 5-lipoxygenase in human neutrophils, whereas 11 behaved as scavenger of superoxide. Onl
- Herencia, Felipe,Ferrandiz, M. Luisa,Ubeda, Amalia,Dominguez, Jose N.,Charris, Jaime E.,Lobo, Gricela M.,Alcaraz, M. Jose
-
p. 1169 - 1174
(2007/10/03)
-