130768-87-5Relevant academic research and scientific papers
An organocatalytic asymmetric allylic alkylation allows enantioselective total synthesis of hydroxymetasequirin-a and metasequirin-b tetramethyl ether diacetates
Wang, Pu-Sheng,Zhou, Xiao-Le,Gong, Liu-Zhu
supporting information, p. 976 - 979 (2014/03/21)
The first highly stereoselective organocatalytic intermolecular allylic alkylation of allylic alcohols with 1,3-dicarbonyls has been developed to allow the first enantioselective total synthesis of hydroxymetasequirin-A and metasequirin-B tetramethyl ethe
Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors
Salum, Lívia B.,Altei, Wanessa F.,Chiaradia, Louise D.,Cordeiro, Marlon N.S.,Canevarolo, Rafael R.,Melo, Carolina P.S.,Winter, Evelyn,Mattei, Bruno,Daghestani, Hikmat N.,Santos-Silva, Maria Cláudia,Creczynski-Pasa, Tania B.,Yunes, Rosendo A.,Yunes, José A.,Andricopulo, Adriano D.,Day, Billy W.,Nunes, Ricardo J.,Vogt, Andreas
supporting information, p. 501 - 510 (2013/07/25)
Based on classical colchicine site ligands and a computational model of the colchicine binding site on beta tubulin, two classes of chalcone derivatives were designed, synthesized and evaluated for inhibition of tubulin assembly and toxicity in human canc
NBS-mediated cyclization of trans-cinnamic alcohols
Chang, Meng-Yang,Tsai, Chung-Yu,Wu, Ming-Hao
, p. 6364 - 6370 (2013/07/26)
An efficient and straightforward three-step synthetic route toward 2,4-disubstituted-3-bromooxetanes 5 with the trans-trans contiguous stereogenic centers is developed from functionalized chalcones 3 via NaBH 4-mediated reduction of chalcones 3
Synthesis and biological evaluation of 3′,4′,5′-trimethoxychalcone analogues as inhibitors of nitric oxide production and tumor cell proliferation
Rao, Yerra Koteswara,Fang, Shih-Hua,Tzeng, Yew-Min
experimental part, p. 7909 - 7914 (2010/03/25)
A series of 23 3′,4′,5′-trimethoxychalcone analogues was synthesized and their inhibitory effects on nitric oxide (NO) production in LPS/IFN-γ-treated macrophages, and tumor cell proliferation has been investigated. 4-Hydroxy-3,3′,4′,5′-tetramethoxychalco
Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents
Bhat,Dhar,Puri,Saxena,Shanmugavel,Qazi
, p. 3177 - 3180 (2007/10/03)
A series of substituted chalcones and their corresponding pyrazoles were synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 93 compounds screened, 8 compounds, 1s, 3i,j,n, 4i,j,n and 4s, showed marked activity. Compounds 4j,n and 4s were found to be the most promising in this study. SAR is also discussed.
Synthesis and anti-inflammatory activity of chalcone derivatives
Herencia, Felipe,Ferrandiz, M. Luisa,Ubeda, Amalia,Dominguez, Jose N.,Charris, Jaime E.,Lobo, Gricela M.,Alcaraz, M. Jose
, p. 1169 - 1174 (2007/10/03)
Chalcones and their derivatives were synthesized and evaluated for their anti-inflammatory activity. In vitro, chalcones 2, 4, 8, 10 and 13 inhibited degranulation and 5-lipoxygenase in human neutrophils, whereas 11 behaved as scavenger of superoxide. Onl
