ENANTIOSELECTIVE ALKYLATION OF α-AMINO CARBANIONSTHE SYNTHESIS OF (S)-1-ALKYL-1,2,3,4 TETRAHYDROISOQUINOLINES
A series of chiral amino alcohols transformed into the formamidine derivative of 1,2,3,4-tetrahydroisoquinolines were evaluated as chiral dipole-stabilized anions.Alkylation with alkyl halides provided the 1-alkyl-1,2,3,4-tetrahydroisoquinolines in both e