130948-34-4

Basic information

• Product Name: [(2S,5R)-5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)tetrahydrofuran-2-yl]methanol
• Synonyms: 2-furanmethanol, 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)tetrahydro-, (2S,5R)-; 4-Amino-1-(2,3-dideoxy-.beta.-D-glycero-pentofuranosyl)-1H-imidazo[4,5-c]pyridine; 4-Amino-1-(2,3-dideoxy-beta-D-glycero-pentofuranosyl)-1H-imidazo(4,5-c)pyridine
• CAS NO: 130948-34-4
• Molecular Formula: C₁₁H₁₄N₄O₂
• Molecular Weight: 234.2545
• Mol File: 130948-34-4.mol

Chemical Properties

• Boiling Point: 532.4°C at 760 mmHg
• Flash Point: 275.8°C
• Density: 1.61g/cm³
• Vapor Pressure: 3.64E-12mmHg at 25°C
• Refractive Index: 1.762
• CAS DataBase Reference: [(2S,5R)-5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)tetrahydrofuran-2-yl]methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [(2S,5R)-5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)tetrahydrofuran-2-yl]methanol(130948-34-4)
• EPA Substance Registry System: [(2S,5R)-5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)tetrahydrofuran-2-yl]methanol(130948-34-4)

Safety Data

• Hazardous Substances Data: 130948-34-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
[(2S,5R)-5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)tetrahydrofuran-2-yl]methanol is used as a key compound in the pharmaceutical industry for the development of new drugs. Its unique structure, which includes a fused imidazole and pyridine ring system along with a tetrahydrofuran ring, may contribute to the creation of novel therapeutic agents with specific targeting capabilities and improved pharmacological properties.
Used in Biochemical Research:
In the field of biochemical research, [(2S,5R)-5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)tetrahydrofuran-2-yl]methanol serves as a valuable molecule for studying various biological processes and interactions. Its structural features can be exploited to probe the mechanisms of enzyme inhibition, receptor binding, and other cellular activities, potentially leading to a better understanding of disease pathways and the discovery of new therapeutic targets.

Upstream product

• 4330-21-6 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride 
• 2770-01-6 4-chloro-1H-imidazo[4,5-c]pyridine 
• 78582-13-5 4-Chloro-1-<2-deoxy-3,5-bis-O-(4-methylbenzoyl)-β-D-erythropentofuranosyl>-1H-imidazo<4,5-c>pyridine 
• 131425-01-9 4-chloro-1-(2',3'-dideoxy-5'-O-<(1'',1 ''-dimethylethyl)dimethylsilyl>-β-D-glycero-pentofuranosyl)-1H-imidazo<4,5-c>pyridine 
• 78582-15-7 4-chloro-1-(2'-deoxy-β-D-erythro-pentofuranosyl)-1H-imidazo<4,5-c>pyridine 
• 130948-31-1 4-Chloro-1-<2-deoxy-5-O-(4-methoxytrityl)-3-O-phenoxy(thiocarbonyl)-β-D-erythropentofuranosyl>-1H-imidazo<4,5-c>pyridine 
• 130948-30-0 4-Chloro-1-<2-deoxy-5-O-(4-methoxytrityl)-β-D-erythropentofuranosyl>-1H-imidazo<4,5-c>pyridine 
• 130948-32-2 4-Chloro-1-<2,3-dideoxy-5-O-(4-methoxytrityl)-β-D-glyceropentofuranosyl>-1H-imidazo<4,5-c>pyridine 
• 221459-89-8 (2RS,5S)-5-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>tetrahydrofuran-2-ol 
• 131487-19-9 2,3-dideoxy-5-O-<(1,1-dimethylethyl)dimethylsilyl>-α/β-D-glycero-pentofuranosyl chloride 
• 130948-33-3 4-chloro-1-(2',3'-dideoxy-β-D-glycero-pentofuranosyl)-1H-imidazo<4,5-c>pyridine 

Downstream Products

• 214121-87-6 2,3-dideoxyribofuranose 
• 6811-77-4 3-deazaadenine 

Relevant articles and documents

Purine analog nucleoside and nucleotide compounds

The invention concerns nucleoside derivatives of the formula I STR1 in which Ba signifies an indolyl (A), benzimidazolyl (B), pyrrolopyridinyl (C), imidazopyridinyl (D), triazolopyrimidinyl (E), imidazotriazinyl (F) or imidazopyrimidinyl (G) group substituted by R1, R2 and R3, in which R1, R2 and R3, which can be the same or different, signify hydrogen, halogen, a C1 -C7 -alkyl, C2 -C7 -alkenyl, hydroxy, mercapto, C1 -C7 -alkylthio, C1 -C7 -alkoxy, C2 -C7 -alkenyloxy, ar-C1 -C5 -alkyl, ar-C2 -C5 -alkenyl, ar-C1 -C5 -alkoxy, ar-C2 -C5 -alkenyloxy, aryloxy, nitro, amino-C1 -C7 -alkyl, C1 -C7 -alkylamino-C1 -C7 -alkyl, di-C1 -C7 -alkylamino-C1 -C7 -alkyl, amino, a substituted amino group --NMR4 or --N(R4)2 or an imino group --N=CH--R4, and R4 has the meaning given in the description, R5, R6, R7 and R8 each signify hydrogen or one or two of the radicals R5, R6, R7 and R8 a hydroxyl, halogen, cyano, azido or a substituted amino group --NHR4 or --N(R4)2 or R5 and R7 can together represent a further bond between C-2' and C-3' and Y represents hydrogen or a C1 -C7 -alkylcarbonyl, monophosphate, diphosphate or triphosphate group, whereby "aryl" signifies a phenyl or naphthyl group and "hetaryl" a furanyl, thienyl or pyridyl group, as well as their possible anomers, N7 - or N9 -regioisomers (purine nomenclature), tautomers and salts.