2770-01-6

Basic information

• Product Name: 4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE
• Synonyms: 4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE;3H-IMidazo[4,5-c]pyridine, 4-chloro-
• CAS NO: 2770-01-6
• Molecular Formula: C₆H₄ClN₃
• Molecular Weight: 153.572
• EINECS: 1592732-453-0
• Product Categories: Heterocycle-Pyridine series
• Mol File: 2770-01-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 179-181 °C
• Boiling Point: 455.436 °C at 760 mmHg
• Flash Point: 261.722 °C
• Appearance: /
• Density: 1.532 g/cm³
• Vapor Pressure: 4.75E-08mmHg at 25°C
• Refractive Index: 1.72
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)
• PKA: 7.93±0.40(Predicted)
• CAS DataBase Reference: 4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE(2770-01-6)
• EPA Substance Registry System: 4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE(2770-01-6)

Safety Data

• Hazardous Substances Data: 2770-01-6(Hazardous Substances Data)

Usage

Uses

4-Chloro-1H-imidazo[4,5-c]pyridine is used as a reagent in the synthesis of 3-bromo-3-deazaneplanocin and 3-bromo-3-deazaaristeromycin, compounds which exhibit antiviral activity.

InChI:InChI=1/C6H4ClN3/c7-6-5-4(1-2-8-6)9-3-10-5/h1-3H,(H,9,10)

Upstream product

• 3243-24-1 imidazo<4,5-c>pyridine-4-one 
• 39217-08-8 2-chloropyridine-3,4-diamine 
• 149-73-5 trimethyl orthoformate 
• 129266-20-2 4-chloro-3-(2'-deoxy-β-D-erythro-pentofuranosyl)-3H-imidazo<4,5-c>pyridine 
• 122-51-0 orthoformic acid triethyl ester 
• 14036-06-7 diethoxymethyl acetate 
• 78582-15-7 4-chloro-1-(2'-deoxy-β-D-erythro-pentofuranosyl)-1H-imidazo<4,5-c>pyridine 

Downstream Products

• 272-97-9 Imidazo<4,5-c>pyridin 
• 1207615-07-3 7H-imidazo[4,5-c]tetrazo[1,5-a]pyridine 
• 881844-11-7 4-chloro-1-(p-methoxybenzyl)-1H-imidazo[4,5-c]pyridine 
• 50432-68-3 4-chloro-1-methyl-1H-imidazo(4,5-c)pyridine 
• 87034-78-4 4-chloro-3-methyl-3H-imidazo[4,5-c]pyridine 
• 1523571-14-3 tert-butyl (tert-butoxycarbonyl)(7-chloro-1H-imidazo[4,5-c]pyridin-4-yl)carbamate 

Relevant articles and documents

NITROGEN HETEROARYL DERIVATIVE HAVING CSF1R INHIBITORY ACTIVITY, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

This application describes a nitrogen heteroaryl derivative having CSF1R inhibitory activity, and a preparation method therefor and an application thereof. Compounds in the present invention has a structure represented by formula (I) as below, and the definition on substituents is as stated in the description and the claims. The compounds in the this application can be widely applied to preparation of drugs for treating cancer, tumor, autoimmune disease, metabolic disease, or metastatic disease, in particular ovarian cancer, pancreatic cancer, prostate cancer, breast cancer, cervical cancer, glioblastoma, multiple myeloma, metabolic disease, neurodegenerative disease, metastasis of primary tumor sites, or osseous metastatic cancer, and a new generation of CSF1R inhibitor drugs is expected to be developed.

Design and synthesis of purine analogues as highly specific ligands for FcyB, a ubiquitous fungal nucleobase transporter

In the course of our study on fungal purine transporters, a number of new 3-deazapurine analogues have been rationally designed, based on the interaction of purine substrates with the Aspergillus nidulans FcyB carrier, and synthesized following an effective synthetic procedure. Certain derivatives have been found to specifically inhibit FcyB-mediated [3H]-adenine uptake. Molecular simulations have been performed, suggesting that all active compounds interact with FcyB through the formation of hydrogen bonds with Asn163, while the insertion of hydrophobic fragments at position 9 and N6 of 3-deazaadenine enhanced the inhibition.

Synthesis of 3-deaza-2'-deoxyadenosine and 3-deaza-2',3'-dideoxyadenosine: Glycosylation of the 4-chloroimidazo[4,5-c]pyridinyl anion

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