Synthesis and in vitro activity of new cephalosporin derivatives containing a benzoxazolone ring
New cephalosporin derivatives containing a benzoxazolone ring in the side acylamino chain are synthesized using chlorides of non-substituted and halogen substituted (2-benzoxazolone-3-yl) acetic acid for the acylation of the 7-aminodesacetoxy-cephalosporanic acid and 7-aminocephalosoranic acid amino group. Some of these new compounds exhibit a biological activity higher than that of cephalexin and cephazolin against clinical strains of Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus group A and B.
Kalcheva,Mincheva,Andreeva
p. 1030 - 1034
(2007/10/02)
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