13108-19-5

Basic information

• Product Name: 10-AMINODECANOIC ACID
• Synonyms: 10-AMINODECANOIC ACID;Decanoic acid, 10-aMino-;10-Aminodecanoic Aci
• CAS NO: 13108-19-5
• Molecular Formula: C₁₀H₂₁NO₂
• Molecular Weight: 187.28
• EINECS: 236-033-4
• Product Categories: pharmacetical
• Mol File: 13108-19-5.mol

Chemical Properties

• Melting Point: 177 °C
• Boiling Point: 319.8°Cat760mmHg
• Flash Point: 147.2°C
• Appearance: /
• Density: 0.975g/cm³
• Vapor Pressure: 6.91E-05mmHg at 25°C
• Refractive Index: 1.469
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.78±0.10(Predicted)
• CAS DataBase Reference: 10-AMINODECANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 10-AMINODECANOIC ACID(13108-19-5)
• EPA Substance Registry System: 10-AMINODECANOIC ACID(13108-19-5)

Safety Data

• Hazardous Substances Data: 13108-19-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
10-AMINODECANOIC ACID is used as a pharmaceutical drug for the treatment of excessive bleeding and prevention of blood clot formation during and after surgery. It functions by inhibiting the activity of plasmin, an enzyme that can break down blood clots, thus providing a crucial intervention in managing bleeding episodes.
Used in Chemical Industry:
10-AMINODECANOIC ACID is used as a building block in the synthesis of various polymers, including nylon. Its low environmental impact and non-toxic properties make it a valuable component in the development of new materials and products in the chemical sector.

InChI:InChI=1/C10H21NO2/c11-9-7-5-3-1-2-4-6-8-10(12)13/h1-9,11H2,(H,12,13)

Upstream product

• 103799-79-7 11-hydroxyimino-triacontanoic acid 
• 7664-93-9 sulfuric acid 
• 99175-22-1 10,10-dichloro-dec-9-enylamine 
• 123-99-9 azelaic acid 
• 37027-56-8 10-chlorodecanoic acid 
• 1009-89-8 azacycloundecan-2-one 
• 110-42-9 Methyl decanoate 
• 1679-53-4 10-hydroxydecanoic acid 
• 25601-41-6 methyl 9-decenoate 
• 50530-12-6 10-bromodecanoic acid 
• 41059-02-3 9-bromononanoic acid 
• 103565-56-6 5-[5-(hydroxyimino-methyl)-[2]thienyl]-valeric acid methyl ester 
• 100370-91-0 5-[5-(acetylamino-methyl)-[2]thienyl]-valeric acid 
• 78845-71-3 5-(5-formyl-thiophen-2-yl)-pentanoic acid methyl ester 

Downstream Products

• 173606-50-3 10-(N-tert-butoxycarbonyl)aminodecanoic acid 
• 191932-98-6 (10-aminodecanoyl)-Ser-Lys-2-cyclohexylethylamide 
• 59178-93-7 (11-Methacryloyl-amino)undecansaeure 
• 195302-79-5 10-<(phenylmethoxy)carbonylamino>decanoic acid 

Relevant articles and documents

Synthesis and application of an N-acylated l-homoserine lactone derivatized affinity matrix for the isolation of quorum sensing signal receptors

The design and synthesis of an agarose resin functionalized with a Gram-negative quorum sensing (QS) signaling molecule analogue is described. The modified resin was utilized in affinity pull-down assays to successfully isolate QscR, a LuxR-type QS receptor from Pseudomonas aeruginosa. This resin may facilitate the identification of novel QS signal receptors using affinity chromatography techniques.

Multi-enzymatic cascade reactions with Escherichia coli-based modules for synthesizing various bioplastic monomers from fatty acid methyl esters?

Multi-enzymatic cascade reaction systems were designed to generate biopolymer monomers using Escherichia coli-based cell modules, capable of carrying out one-pot reactions. Three cell-based modules, including a ω-hydroxylation module (Cell-Hm) to convert fatty acid methyl esters (FAMEs) to ω-hydroxy fatty acids (ω-HFAs), an amination module (Cell-Am) to convert terminal alcohol groups of the substrate to amine groups, and a reduction module (Cell-Rm) to convert the carboxyl groups of fatty acids to alcohol groups, were constructed. The product-oriented assembly of these cell modules involving multi-enzymatic cascade reactions generated ω-ADAs (up to 46 mM), α,ω-diols (up to 29 mM), ω-amino alcohols (up to 29 mM) and α,ω-diamines (up to 21 mM) from 100 mM corresponding FAME substrates with varying carbon chain length (C8, C10, and C12). Finally 12-ADA and 1,12-diol were purified with isolated yields of 66.5% and 52.5%, respectively. The multi-enzymatic cascade reactions reported herein present an elegant ‘greener’ alternative for the biosynthesis of various biopolymer monomers from renewable saturated fatty acids.

Parallel anti-sense two-step cascade for alcohol amination leading to ω-amino fatty acids and α,ω-diamines

Running two two-step cascades in parallel anti-sense to transform an alcohol to an amine allowed the conversion of ω-hydroxy fatty acids (ω-HFAs) and α,ω-diols to the corresponding ω-amino fatty acids (ω-AmFAs) and α,ω-diamines, respectively. The network required only two enzymes namely an aldehyde reductase (AHR) and a transaminase (TA). Benzylamine served on the one hand as amine donor and on the other hand after deamination to benzaldehyde also as oxidant. All ω-HFAs tested were efficiently transformed to their corresponding ω-AmFAs using purified enzymes as well as a whole-cell system, separately expressing both the enzymes, with conversions ranging from 80-95%. Additionally, a single-cell co-expressing all enzymes successfully produced the ω-AmFAs as well as the α,ω-diamines with >90% yield. This system was extended by employing a lactonase, enabling the transformation of ?-caprolactone to its corresponding ω-AmFA with >80% conversion.

RENEWABLY DERIVED POLYAMIDES AND METHODS OF MAKING THE SAME

Methods of making polyamides from renewable materials, such as natural oils, are generally disclosed herein. In some embodiments, the polyamides are nylon-10. In some such embodiments, nylon-10 is made by polymerizing 10-aminodecanoic acid, or esters thereof. In some further such embodiments, the 10-aminodecanoic acid monomers (or esters thereof) are derived from natural oils via the metathesis of unsaturated fatty acid moieties of the natural oil.

Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites

N-Myristoyltransferase (NMT) has been shown to be essential in Leishmania and subsequently validated as a drug target in Plasmodium. Herein, we discuss the use of antifungal NMT inhibitors as a basis for inhibitor development resulting in the first sub-micromolar peptidomimetic inhibitors of Plasmodium and Leishmania NMTs. High-resolution structures of these inhibitors with Plasmodium and Leishmania NMTs permit a comparative analysis of binding modes, and provide the first crystal structure evidence for a ternary NMT-Coenzyme A/myristoylated peptide product complex. This journal is

COVALENT INHIBITION OF BACTERIAL QUORUM SENSING

Inhibitors of bacterial communication, such as quorum sensing, and method of use and manufacture thereof.

Covalent inhibition of bacterial quorum sensing

Chemical coordination of gene expression among bacteria as a function of population density is regulated by a mechanism known as 'quorum sensing' (QS). QS in Pseudomonas aeruginosa, an opportunistic pathogen that causes disease in immunocompromised patients, is mediated by binding of the transcriptional activator, LasR, to its ligand, 3-oxo-C12-HSL, leading to population-wide secretion of virulence factors and biofilm formation. We have targeted QS in P. aeruginosa with a set of electrophilic probes designed to covalently bind Cys79 in the LasR binding pocket, leading to specific inhibition of QS-regulated gene expression and concomitant reduction of virulence factor secretion and biofilm formation. This first example of covalent modification of a QS receptor provides a new tool to study molecular mechanisms of bacterial group behavior and could lead to new strategies for targeting bacterial virulence.

MACROCYLIC PEPTIDES USEFUL IN THE TREATMENT OF THROMBIN RELATED DISORDERS

Compounds of Formula I STR1 and Formula III STR2 which are useful in the treatment of thrombin and trypsin related disorders.