Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: New lead structures for monitoring gene expression in vivo
Novel C-6 substituted pyrimidine derivatives are good substrates of herpes simplex virus type 1 thymidine kinase (HSV1-TK). Enzyme kinetic experiments showed that our lead compound, N-methyl DHBT (N-methyl-6-(1,3-dihydroxyisobutyl) thymine; N-Me DHBT), is
Martic, Miljen,Pernot, Lucile,Westermaier, Yvonne,Perozzo, Remo,Kraljevic, Tatjana Gazivoda,Kristafor, Svjetlana,Raic-Malic, Silvana,Scapozza, Leonardo,Ametamey, Simon