26305-13-5Relevant articles and documents
DIAMINOPYRIMIDINES USEFUL AS INHIBITORS OF THE HUMAN RESPIRATORY SYNCYTIAL VIRUS (RSV)
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Page/Page column 40, (2013/08/28)
This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit RSV infection and/or replication; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
Synthesis of modified uracil and cytosine nucleobases using a microwave-assisted method
Burgula, Laxmi Narayana,Radhakrishnan,Kundu, Lal Mohan
supporting information; experimental part, p. 2639 - 2642 (2012/06/30)
Modified nucleobases and nucleic acids have found many biological and pharmaceutical applications. Here we report a microwave-directed synthesis of a variety of modified uracil and cytosine nucleobases with high yields under solvent-free conditions. The reaction yields were further improved by addition of Lewis acid. The crystal structures of 5-isopropyl-6-methyluracil and 6-phenyluracil were also determined.
Solid-phase synthesis (SPS) of substituted uracils via Oxone cleavage methodology
Petricci, Elena,Renzulli, Michela,Radi, Marco,Corelli, Federico,Botta, Maurizio
, p. 9667 - 9670 (2007/10/03)
An original and highly efficient Oxone cleavage methodology for the solid-phase synthesis of substituted uracils has been developed. An example of application of this methodology to the solid-phase synthesis of uridine derivatives is also reported.
New procedures for the synthesis of heterocyclic substituted and 2,4-difunctionalized pyrimidines
Garcia Martinez, Antonio,Herrera Fernandez, Antonio,Moreno Jimenez, Florencio,Munoz Martinez, Pablo J.,Alonso Martin, Cristina,Subramanian, Laksminarayanapuran R.
, p. 7973 - 7982 (2007/10/03)
N-Tosyl-2-and -3-acetylpyrrols 1 or N-tosyl-2-pyrrolidone 5 were condensed with cyano compounds in the presence of triflic anhydride (Tf2O) to yield heteroarylpyrimidines. 2,4-Difunctionalized pyrimidines were obtained by reaction of the corresponding 2,4-bis(methylsulfonyl)pyrimidines with nucleophiles.
A useful methodology for the regioselective deprotection of 1,3-dibenzyluracils
Botta,Summa,Saladino,Nicoletti
, p. 2181 - 2187 (2007/10/02)
A practical, regioselective N-1 deprotection of 1,3-dibenzyl uracils 2 a-e is described. The same experimental procedure and longer reaction time afforded the complete deprotection of the uracils.
6-ALKYL AND 5,6-DIALKYL-2-METHOXY-4(3H)-PYRIMIDINONES IN THE TRANSFORMATIONS OF PYRIMIDINES-2 SYNTHESIS AND CONVERSION INTO ALKYLURACILS AND 2-ALKOXY-4(3H)-PYRIMIDINONES
Botta, M.,Cavalieri, M.,Ceci, D.,Angelis, F. De,Finizia, G.,Nicoletti, R.
, p. 3313 - 3320 (2007/10/02)
The synthesis of 6-alkyl and 5,6-dialkyl-2-methoxy-4(3H)-pyrimidinones 3 is described.Their versatility to be transformed into 6-alkyl and 5,6-dialkyluracils 4(a-h), 6-alkyl and 5,6-dialkyl-3-methyluracils 7(a,e,f) and 6-alkyl and 5,6-dialkyl-2-alkoxy-4(3H)-pyrimidinones 5(a-i) is also shown.