- Glucose-responsive insulin multivesicular liposome as well as preparation method and application thereof
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The invention discloses a glucose-responsive insulin multi-vesicular liposome as well as a preparation method and application thereof. The liposome is a glucose-responsive insulin multi-vesicular liposome loaded with a phenylboronic acid derivative, gluco
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Paragraph 0041-0044
(2021/07/21)
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- SUGAR-RESPONSIVE GEL AND MEDICINE ADMINISTERING DEVICE
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Disclosed are a sugar-responsive gel and a medicine administering device having a pKa more suitable for use in a body environment and capable of administering medicine more autonomously than before. A sugar-responsive gel and an insulin administering device having a pKa more suitable for use in a body environment and capable of administering insulin more autonomously than before, wherein under a body condition of pKa of 7.4 or less and temperature of 35° C.-40° C., when the glucose concentration increases, insulin can be released from a gel body in response thereto, and when the glucose concentration decreases, insulin release from the gel body can be suppressed.
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Paragraph 0060; 0061
(2013/03/28)
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- A synthetic approach toward a self-regulated insulin delivery system
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Protein-free: A hydrogel containing phenylboronate was optimized so as to undergo rapid glucose-dependent changes in the state of hydration under physiological aqueous conditions. A localized dehydration of the gel surface to form a "skin layer" enabled control of the release of insulin from the gel. This dehydration is induced by fluctuations in the glucose concentration in the range between normo- and hyperglycemia. Copyright
- Matsumoto, Akira,Ishii, Takehiko,Nishida, Junko,Matsumoto, Hiroko,Kataoka, Kazunori,Miyahara, Yuji
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supporting information; experimental part
p. 2124 - 2128
(2012/04/18)
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- Phenylboronic Acid Monomer and Phenylboronic Acid Polymer
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Disclosed are a phenylboronic acid monomer and a phenylboronic acid polymer, each of which can have a pKa value suitable for the use under physiological environments and can be used for various applications. The pheanylboronic acid monomer has a structure represented by formula (13) and therefore has high hydrophilicity, can have a satisfactorily low pKa value when the phenyl ring is fluorinated, and can have a polymerizable unsaturated bond. The phenylboronic acid monomer has high hydrophilicity at a pKa value of 7.4 or less which is a physiological level, and can be polymerized with a wide variety of monomers to produce polymers suitable for the intended purposes.
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Page/Page column 4-5
(2012/11/13)
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