131773-23-4

Basic information

• Product Name: 2-CHLORO-IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE
• Synonyms: IFLAB-BB F2124-0672;AURORA KA-4215;2-CHLORO-IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE;IMidazo[1,2-a]pyridine-3-carboxaldehyde, 2-chloro-
• CAS NO: 131773-23-4
• Molecular Formula: C8H5ClN2O
• Molecular Weight: 180.59
• Mol File: 131773-23-4.mol

Chemical Properties

• Appearance: /
• Density: 1.42g/cm³
• Refractive Index: 1.662
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-CHLORO-IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE(131773-23-4)
• EPA Substance Registry System: 2-CHLORO-IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE(131773-23-4)

Safety Data

• Hazardous Substances Data: 131773-23-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
2-CHLORO-IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE is utilized as a key building block in the synthesis of pharmaceutical intermediates, contributing to the development of new drugs. Its unique structure and chemical properties make it a valuable component in the creation of novel therapeutic agents.
Used in Agrochemical Synthesis:
In the agrochemical industry, 2-CHLORO-IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE is employed as a precursor in the synthesis of various agrochemicals, potentially enhancing crop protection and yield through the development of innovative pesticides and other agricultural chemicals.
Used in Medicinal Chemistry and Drug Design:
2-CHLORO-IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE serves as a target for exploration in medicinal chemistry, where its specific chemical and biological properties are harnessed to design and optimize new drug candidates with improved efficacy and safety profiles.

InChI:InChI=1/C8H5ClN2O/c9-8-6(5-12)11-4-2-1-3-7(11)10-8/h1-5H

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 3999-05-1 2-chloroimidazo[1,2-a]pyridine 
• 126202-06-0 2-(2-imino-1,2-dihydropyridin-1-yl)acetic acid 
• 504-29-0 2-aminopyridine 

Relevant articles and documents

Synthesis and Physicochemical Properties of New Chalcones Containing a 2-Chloroimidazo[1,2-a]pyridine Fragment

Abstract: New chalcones containing a 2-chloroimidazo[1,2-a]pyridine fragment have been synthesized, and their optical properties have been studied. The Stokes shifts, forbidden band gap widths, molar absorption coefficients, and fluorescence quantum yields have been determined on the basis of their absorption and emission spectra. Introduction of an additional thiophene fragment into the chalcone molecules produced an increase of the Stokes shift, red shift of the emission maximum, and sharp increase of the quantum yield (up to 22%). The synthesized chalcones showed high thermal stability and good film-forming properties, and films obtained therefrom exhibited an ordered structure.

Synthesis and Structure of 2-(1Н-Indol-1-yl)-6-ferrocenyl-4-(2-chloroimidazo[1,2-a]pyridin-3-yl)pyrimidine

A 2,4,6-trisubstituted pyrimidine including a 2-(1H-indol-1-yl) substituent was synthesized by the reaction of 1-ferrocenyl-3-(2-chloroimidazo[1,2-a]pyridin-3-yl)propanone with 2,5-dimethoxytetrahydrofuran. The structure of the synthesized compound was confirmed by IR and 1Н NMR spectroscopy, and X-ray diffraction analysis. It has been shown that the ferrocene-containing compounds synthesized in the present work all demonstrate intramolecular charge transfer which is evidenced by the observation of the corresponding absorption bands with λmaxabs > 480 nm. The oxidation potential of ferrocene (EoxFc) in all the compounds is higher than 700 mV.

Insights into selenylation of imidazo[1,2-a]pyridine: synthesis, structural and antimicrobial evaluation

An efficient methodology was developed to synthesize novel organoselenium derivatives of formyl-substituted imidazo[1,2-a]pyridine by nucleophilic aromatic substitution with aryl selenolate anions generated in situ through the reduction of different disel