126202-06-0

Basic information

• Product Name: 1(2H)-Pyridineaceticacid,2-imino-(9CI)
• Synonyms: 1(2H)-Pyridineaceticacid,2-imino-(9CI);2-(2-Iminopyridin-1(2H)-yl)acetic acid
• CAS NO: 126202-06-0
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.152
• Product Categories: GLYCINESCAFFOLD
• Mol File: 126202-06-0.mol

Chemical Properties

• Boiling Point: 308.0±44.0 °C(Predicted)
• Appearance: /
• Density: 1.28±0.1 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.78±0.10(Predicted)
• CAS DataBase Reference: 1(2H)-Pyridineaceticacid,2-imino-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Pyridineaceticacid,2-imino-(9CI)(126202-06-0)
• EPA Substance Registry System: 1(2H)-Pyridineaceticacid,2-imino-(9CI)(126202-06-0)

Safety Data

• Hazardous Substances Data: 126202-06-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1(2H)-Pyridineacetic acid, 2-imino-(9CI) is used as a key intermediate in the synthesis of organoselenium imidazo[1,2-a]pyridine compounds. These compounds have been studied for their antimicrobial properties, making them potentially valuable in the development of new antibiotics and antifungal agents to combat drug-resistant infections.
Used in Chemical Industry:
In the chemical industry, 1(2H)-Pyridineacetic acid, 2-imino-(9CI) can be utilized as a building block for the creation of various complex organic molecules with diverse applications. Its unique structure allows for further functionalization and modification, enabling the development of new compounds with specific properties and reactivity.

Upstream product

• 504-29-0 2-aminopyridine 
• 3926-62-3 sodium monochloroacetic acid 
• 7748-25-6 potassium chloroacetate 
• 79-11-8 chloroacetic acid 

Downstream Products

• 504-29-0 2-aminopyridine 
• 4597-87-9 2-(N-methylamino)pyridine 
• 56546-36-2 (2-oxo-2H-pyridin-1-yl)-acetic acid 
• 3999-05-1 2-chloroimidazo[1,2-a]pyridine 
• 1452807-18-9 2-(4-fluorophenyl)-3-nitroimidazo[1,2-a]pyridine 
• 22244-94-6 3-nitro-2-(4'-nitrophenyl)imidazo[1,2-a]pyridine 
• 3999-29-9 2-phenylimidazo[1,2-a]pyridin-3-amine 
• 54167-76-9 N-(2-phenyl-imidazo[1,2-a]pyridin-3-yl)-acetamide 
• 1452807-20-3 C₁₇H₁₈N₄O 
• 1452807-21-4 C₁₈H₂₀N₄O 
• 1296335-75-5 C₂₀H₂₂N₄O 
• 171628-63-0 1-Phenyl-3-(2-phenyl-imidazo[1,2-a]pyridin-3-yl)-urea 
• 4926-52-7 2-chloro-3-nitroimidazo[1,2-a]pyridine 
• 1189902-53-1 C₂₁H₁₈N₄O 

Relevant articles and documents

Synthesis and Structure of 2-(1Н-Indol-1-yl)-6-ferrocenyl-4-(2-chloroimidazo[1,2-a]pyridin-3-yl)pyrimidine

A 2,4,6-trisubstituted pyrimidine including a 2-(1H-indol-1-yl) substituent was synthesized by the reaction of 1-ferrocenyl-3-(2-chloroimidazo[1,2-a]pyridin-3-yl)propanone with 2,5-dimethoxytetrahydrofuran. The structure of the synthesized compound was confirmed by IR and 1Н NMR spectroscopy, and X-ray diffraction analysis. It has been shown that the ferrocene-containing compounds synthesized in the present work all demonstrate intramolecular charge transfer which is evidenced by the observation of the corresponding absorption bands with λmaxabs > 480 nm. The oxidation potential of ferrocene (EoxFc) in all the compounds is higher than 700 mV.

Insights into selenylation of imidazo[1,2-a]pyridine: synthesis, structural and antimicrobial evaluation

An efficient methodology was developed to synthesize novel organoselenium derivatives of formyl-substituted imidazo[1,2-a]pyridine by nucleophilic aromatic substitution with aryl selenolate anions generated in situ through the reduction of different disel

Facile synthesis, structural evaluation, antimicrobial activity and synergistic effects of novel imidazo[1,2-a]pyridine based organoselenium compounds

A simple and efficient method has been described to synthesize the hitherto unknown imidazo[1,2-a]pyridine selenides (5a-l) by reaction of 2-chloroimidazo [1,2-a]pyridines with aryl/heteroaryl selenols, generated in situ by reduction of various diselenide

Synthesis and antibacterial activity in?vitro of 2-benzylthioimidazo[1,2-a]pyridine derivatives against pathogenic bacterial

To explore the antibacterial activity, a set of new 2-thiobenzyl-3-nitro-imidazo[1,2-a]pyridine derivatives were synthesized (9a–h) and characterized by NMR 1H, 13C and high-resolution mass (HRMS). These compounds were obtained by interaction between the 3-nitro-imidazo[1,2-a]pyridine isothiouronium salt (7) with benzyl chloride or bromide (8) in the presence of sodium hydroxide (NaOH). Eight (9a–h) of them were evaluated in?vitro on the positive gram bacterium (S. aureus ATCC 29213) and two others negative gram bacteria (P. aeruginosa ATCC 27853 and P. aeruginosa 933 C/21) by methods diffusion in solid medium and liquid macrodilution. Five among the eight compounds (9a, 9d, 9h, 9f and 9g) showed significant antibacterial activity on P. aeruginosa ATCC 27853 and P. aeruginosa 933 C/21with MIC between 7.81 and 250 μg/mL. All compounds were inactive on S. aureus. The compounds 9a and 9g were more potent on the two strains of P. aeruginosa ATCC 27853.

Synthesis and Physicochemical Properties of New Chalcones Containing a 2-Chloroimidazo[1,2-a]pyridine Fragment

Abstract: New chalcones containing a 2-chloroimidazo[1,2-a]pyridine fragment have been synthesized, and their optical properties have been studied. The Stokes shifts, forbidden band gap widths, molar absorption coefficients, and fluorescence quantum yields have been determined on the basis of their absorption and emission spectra. Introduction of an additional thiophene fragment into the chalcone molecules produced an increase of the Stokes shift, red shift of the emission maximum, and sharp increase of the quantum yield (up to 22%). The synthesized chalcones showed high thermal stability and good film-forming properties, and films obtained therefrom exhibited an ordered structure.

Structural Determinants for the Mode of Action of Imidazopyridine DS2 at δ-Containing γ-Aminobutyric Acid Type A Receptors

Despite the therapeutic relevance of δ-containing γ-aminobutyric acid type A receptors (GABAARs) and the need for δ-selective compounds, the structural determinants for the mode and molecular site of action of δ-selective positive allosteric modulator imi

FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS PEST CONTROL AGENTS

The present invention discloses a fused heterocyclic compound of formula (I), wherein, R1, Y, Q, A, G,m and E are as defined in the detailed description. The present invention further discloses methods for their preparation and use of the compounds of formula (I) as a pest control agent.

Double (amino-sulfur generation of formic acid ) - 1,3-propane diester compound and its synthetic method, pharmaceutical composition and use thereof

The invention relates to a bis(aminodithioformate)-1,3-propane diester compound, and synthesis method thereof, a pharmaceutical composition containing the compound and a use, and especially relates to the use in preparing drugs for treating or preventing cancers. The compound is represented as the formula (I), wherein A is selected from substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic group, R1 and R2 are the same or different and are independently selected from hydrogen, alkyl, aryl alkyl or heteroaryl alkyl, or a substituted or unsubstituted heterocyclic ring formed together by the R1, the R2 and an N atom connected with the R1 and the R2.

HETERO-CYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME

The present specification relates to a novel heterocyclic compound and an organic light-emitting device using the same. According to one embodiment of the present specification, provided is a compound in chemical formula 1. The compound of the present specification can be used as an organic matter layer material of an organic light-emitting device.COPYRIGHT KIPO 2016

Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a] pyridine: Expanding structural diversity of C2- and C3-functionalized imidazo[1,2-a]pyridines

Alternative strategies for functionalizing 2-chloro-3-nitroimidazo[1,2-a] pyridine have been developed. Suzuki-Miyaura cross-coupling reaction provided easily the corresponding 2-arylated compounds, and herefrom the nitro group was reduced into amine which afforded amides, anilines, and ureas in the 3-position. The amination of the key compound using a metal-catalyzed reaction was reported. This study highlighted the importance of the nitro group to facilitate the chlorine displacement. Other nucleophilic aromatic substitutions open a route to various products derived from imidazo[1,2-a]pyridine.