1318242-98-6

Basic information

• Product Name: 4-aMinothieno[3,2-d]pyriMidine-7-carboxylic acid
• Synonyms: 4-aMinothieno[3,2-d]pyriMidine-7-carboxylic acid
• CAS NO: 1318242-98-6
• Molecular Formula: C7H5N3O2S
• Molecular Weight: 195.1985
• EINECS: -0
• Mol File: 1318242-98-6.mol

Chemical Properties

• Boiling Point: 512.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.707±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -0.74±0.10(Predicted)
• CAS DataBase Reference: 4-aMinothieno[3,2-d]pyriMidine-7-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-aMinothieno[3,2-d]pyriMidine-7-carboxylic acid(1318242-98-6)
• EPA Substance Registry System: 4-aMinothieno[3,2-d]pyriMidine-7-carboxylic acid(1318242-98-6)

Safety Data

• Hazardous Substances Data: 1318242-98-6(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
4-Aminothieno[3,2-d]pyrimidine-7-carboxylic acid is used as a key intermediate in the synthesis of various pharmaceuticals and biologically active molecules. Its unique structure and properties contribute to the development of novel drugs with potential therapeutic applications.
Used in Drug Discovery and Development:
7-ATP is employed as a promising candidate in drug discovery and development, owing to its potential to be further modified and optimized for specific therapeutic targets. Its heterocyclic nature allows for the design of new chemical entities with improved pharmacological properties.
Used in Organic Synthesis:
In the field of organic synthesis, 4-Aminothieno[3,2-d]pyrimidine-7-carboxylic acid is used as a versatile building block for the synthesis of diverse chemical compounds. Its aromatic and heterocyclic nature enables the creation of a wide range of molecules with various applications in chemistry and related industries.
Used in Pharmaceutical Industry:
4-Aminothieno[3,2-d]pyrimidine-7-carboxylic acid is used as a starting material or intermediate in the pharmaceutical industry for the development of new drugs and therapeutic agents. Its unique structure and properties make it a valuable component in the synthesis of innovative pharmaceuticals with potential applications in treating various diseases and medical conditions.

Upstream product

• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 31169-25-2 7-bromothieno[3,2-d]pyrimidine-4(3H)-one 
• 16234-10-9 3H-thieno[3,2-d]pyrimidin-4-one 
• 1446113-33-2 4-amino-thieno[3,2-d]pyrimidine-7-carbaldehyde 
• 1318132-91-0 7-vinylthieno[3,2-d]pyrimidine-4-amine 
• 1318133-32-2 7-bromothieno[3,2-d]pyrimidine-4-amine 
• 31169-27-4 7-bromo-4-chlorothieno[3,2-d]pyrimidine 

Downstream Products

• 1446111-75-6 4-amino-N-(4-((4-chlorophenyl)amino)-7-methylquinazolin-8-yl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1446111-86-9 4-amino-N-(6-methyl-1-phenoxyisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1446112-11-3 4-amino-N-(1-((4-chloro-3-((dimethylamino)methyl)phenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1446112-26-0 4-amino-N-(6-methyl-1-((3-(methylsulfonamido)phenyl)amino)isoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1446112-28-2 tert-butyl 4-(5-((5-(4-aminothieno[3,2-d]pyrimidine-7-carboxamido)-6-methylisoquinolin-1-yl)amino)-2-chlorobenzyl)piperazine-1-carboxylate 
• 1446112-30-6 4-amino-N-(1-((4-chloro-3-(piperazin-1-ylmethyl)phenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide hydrochloride 
• 1446111-26-7 4-amino-N-(1-((4-chlorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide 

Relevant articles and documents

An Efficient Second-Generation Manufacturing Process for the pan-RAF Inhibitor Belvarafenib

Herein, the development of a streamlined manufacturing process for the pan-RAF inhibitor belvarafenib (GDC-5573) is reported. The process to belvarafenib features a number of efficient key reactions, including a robust and scalable Pd-catalyzed carbonylation reaction to generate thienopyrimidine 2 and a highly chemoselective Pt/V/C-catalyzed nitro group reduction to access the penultimate intermediate 3. The final amide coupling was accomplished by a mild and safe protocol employing N,N,N′,N′-tetramethylchloroformamidinium hexafluorophosphate as the coupling reagent, which afforded belvarafenib on a multikilogram production scale after recrystallization.

FUSED PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON FMS KINASES

Disclosed are a fused pyrimidine derivative of formula (I), and a pharmaceutically acceptable salt, stereoisomer, hydrate and solvate thereof, which have an excellent inhibitory activity on FMS kinases, and a pharmaceutical composition comprising the same is effective in preventing or treating diseases caused by abnormal activation of FMS kinases such as immunologic diseases, metabolic diseases, inflammatory diseases, cancers and tumors.

THIENO[3,2-D]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES

Provided are a thieno[3,2-d]pyrimidine derivative of formula (I) or a pharmaceutically acceptable salt thereof having inhibitory activity for protein kinase, and a pharmaceutical composition comprising same for prevention and treatment of abnormal cell growth diseases.

THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES

Provided are a thieno[3,2-d]pyrimidine derivative of formula (I) or a pharmaceutically acceptable salt thereof having inhibitory activity for protein kinase, and a pharmaceutical composition comprising same for prevention and treatment of abnormal cell growth diseases

THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES

The present invention relates to a thieno[3,2-d]pyrimidine derivative of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, which has an excellent inhibitory activity on protein kinases, and a pharmaceutical composition comprising the same is effective in preventing or treating abnormal cell growth diseases.

THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES

The present invention relates to a thieno[3,2-d]pyrimidine derivative of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, which has an excellent inhibitory activity on protein kinases, and a pharmaceutical composition comprising the same is effective in preventing or treating abnormal cell growth diseases.