1318133-32-2

Basic information

• Product Name: 4-AMino-7-broMo-thieno[3,...
• Synonyms: 4-AMino-7-broMo-thieno[3,...;4-AMino-7-broMo-thieno[3,2-d]pyriMidine;7-broMothieno[3,2-d]pyriMidin-4-aMine
• CAS NO: 1318133-32-2
• Molecular Formula: C₆H₄BrN₃S
• Molecular Weight: 230.08506
• Mol File: 1318133-32-2.mol

Chemical Properties

• Boiling Point: 403.5±40.0 °C(Predicted)
• Appearance: /
• Density: 1.950±0.06 g/cm3(Predicted)
• PKA: 4.07±0.40(Predicted)
• CAS DataBase Reference: 4-AMino-7-broMo-thieno[3,...(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMino-7-broMo-thieno[3,...(1318133-32-2)
• EPA Substance Registry System: 4-AMino-7-broMo-thieno[3,...(1318133-32-2)

Safety Data

• Hazardous Substances Data: 1318133-32-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Amino-7-bromo-thieno[3,... is used as a potential therapeutic agent for various diseases due to its pharmacological properties. Its anti-cancer activity makes it a candidate for the development of new cancer treatments, particularly for solid malignancies. 4-AMino-7-broMo-thieno[3,... may modulate several oncological signaling pathways, potentially inhibiting tumor growth and progression.
Additionally, 4-Amino-7-bromo-thieno[3,...] is used as an anti-inflammatory agent, which could be beneficial in treating conditions characterized by inflammation, such as arthritis or autoimmune diseases.
In the field of Anti-microbial Applications:
4-Amino-7-bromo-thieno[3,...] is used as an antimicrobial agent, potentially effective against a range of bacterial, viral, or fungal infections. Its ability to target specific pathogens could lead to the development of new treatments for infectious diseases.
In Cancer Therapy Research:
4-Amino-7-bromo-thieno[3,...] is used as a kinase inhibitor, which is a significant application in targeted cancer therapies. Kinase inhibitors can selectively target enzymes involved in cancer cell growth, making them a valuable tool in the development of personalized medicine approaches to cancer treatment.
In Drug Delivery Systems:
4-Amino-7-bromo-thieno[3,...] is used in the development of drug delivery systems to enhance its therapeutic applications and efficacy. Novel drug delivery systems, such as organic and metallic nanoparticles, can be employed as carriers for 4-AMino-7-broMo-thieno[3,..., aiming to improve its delivery, bioavailability, and therapeutic outcomes in various medical applications.

Upstream product

• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 31169-25-2 7-bromothieno[3,2-d]pyrimidine-4(3H)-one 
• 31169-27-4 7-bromo-4-chlorothieno[3,2-d]pyrimidine 
• 16234-10-9 3H-thieno[3,2-d]pyrimidin-4-one 

Downstream Products

• 1446111-26-7 4-amino-N-(1-((4-chlorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1318242-98-6 4-amino-thieno[3,2-d]pyrimidine-7-carboxylic acid 
• 1446112-30-6 4-amino-N-(1-((4-chloro-3-(piperazin-1-ylmethyl)phenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide hydrochloride 
• 1446112-28-2 tert-butyl 4-(5-((5-(4-aminothieno[3,2-d]pyrimidine-7-carboxamido)-6-methylisoquinolin-1-yl)amino)-2-chlorobenzyl)piperazine-1-carboxylate 
• 1446112-26-0 4-amino-N-(6-methyl-1-((3-(methylsulfonamido)phenyl)amino)isoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1446112-11-3 4-amino-N-(1-((4-chloro-3-((dimethylamino)methyl)phenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1446111-86-9 4-amino-N-(6-methyl-1-phenoxyisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1446111-75-6 4-amino-N-(4-((4-chlorophenyl)amino)-7-methylquinazolin-8-yl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1318241-43-8 (E)-3-(2-(4-aminothieno[3,2-d]pyrimidine-7-yl)vinyl)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide 
• 1318242-75-9 (E)-3-(2-(4-aminothieno[3,2-d]pyrimidine-7-yl)vinyl)-4-methylbenzoic acid 
• 1318127-08-0 (E)-ethyl-3-(2-(4-aminothieno[3,2-d]pyrimidine-7-yl)vinyl)-4-methyl benzoate 
• 1318126-97-4 7-(4-bromo-3,5-dimethoxystyryl)thieno[3,2-d]pyrimidine-4-amine 

Relevant articles and documents

FUSED PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON FMS KINASES

Disclosed are a fused pyrimidine derivative of formula (I), and a pharmaceutically acceptable salt, stereoisomer, hydrate and solvate thereof, which have an excellent inhibitory activity on FMS kinases, and a pharmaceutical composition comprising the same is effective in preventing or treating diseases caused by abnormal activation of FMS kinases such as immunologic diseases, metabolic diseases, inflammatory diseases, cancers and tumors.

THIENO[3,2-D]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES

Provided are a thieno[3,2-d]pyrimidine derivative of formula (I) or a pharmaceutically acceptable salt thereof having inhibitory activity for protein kinase, and a pharmaceutical composition comprising same for prevention and treatment of abnormal cell growth diseases.

THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES

The present invention relates to a thieno[3,2-d]pyrimidine derivative of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, which has an excellent inhibitory activity on protein kinases, and a pharmaceutical composition comprising the same is effective in preventing or treating abnormal cell growth diseases.

THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES

Provided are a thieno[3,2-d]pyrimidine derivative of formula (I) or a pharmaceutically acceptable salt thereof having inhibitory activity for protein kinase, and a pharmaceutical composition comprising same for prevention and treatment of abnormal cell growth diseases

THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES

The present invention relates to a thieno[3,2-d]pyrimidine derivative of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, which has an excellent inhibitory activity on protein kinases, and a pharmaceutical composition comprising the same is effective in preventing or treating abnormal cell growth diseases.

BICYCLIC HETEROARYL DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE

The present invention relates to a novel bicyclic heteroaryl derivative, a pharmaceutically acceptable salt thereof, a hydrate thereof, and a solvate thereof having an improved inhibitory activity for protein kinases, and a pharmaceutical composition for preventing or treating an abnormal cell growth disorder comprising same as an active ingredient.