cas 131896-42-9, D-4-THIAZOLYLALANINE | Articles data ｜lookchem

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131896-42-9

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Caldwell,Fox
p. 2935
(1951)
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Enantioselective synthesis of (S)-3-(4-thiazolyl)-2-tert- butoxycarbonylaminopropionic acid: A chiral building block for renin inhibitor
(S)-3-(4-Thiazolyl)-2-tert-butoxycarbonylaminopropionic acid (6), an important structural constituent of the renin inhibitor, has been synthesized from (Z)-3-(4-thiazolyl)-2-benzoylaminoprop-2-enoic acid (4b) by enantioselective hydrogenation using the Ru
Yuasa, Yoshifumi,Tsuruta, Haruki,Yuasa, Yoko
p. 2385 - 2392
(2007/10/03)

Substituted quinoxaline-2-ones as glutamate receptor antagonists
A novel series of substituted quinoxaline 2-ones useful as neuroprotective agents are taught. Novel intermediates, processes of preparation, and pharmaceutical compositions containing the compounds are also taught. The compounds are glutamate receptor antagonists and are useful in the treatment of stroke, cerebral ischemia, or cerebral infarction resulting from thromboembolic or hemorrhagic stroke, cerebral vasospasms, hypoglycemia, cardiac arrest, status epilepticus, perinatal asphyxia, anoxia, seizure disorders, pain, Alzheimer's, Parkinson's, and Huntington's Diseases.
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(2008/06/13)

COMPOUNDS CONTAINING A FUSED BICYCLE RING AND PROCESSES THEREFOR
Compounds of the formula STR1 wherein X is O or S--(O) t ; n is one or two; m is zero or one; Y is CH 2, O, or S--(O) t provided that Y is O or S--(O) t only when m is one; and A is STR2 are dual inhibitors of NEP and ACE. Compounds wherein A is STR3 are selective ACE inhibitors. Also disclosed are methods of preparation and intermediates.
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(2008/06/13)

Studies of unnatural amino acids and their peptides. II. The syntheses of DL-beta-(4-thiazolyl)-alpha-alanine and its peptides.
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Watanabe,Kuwata,Sakata,Matsumura
p. 2473 - 2476
(2007/10/04)

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Chemical Properties

Boiling Point: 353.32 °C at 760 mmHg
Flash Point:167.482 °C
Density: 1.433 g/cm³
Storage Temp.:Store at -15°C
Refractive Index: 1.64
PKA: 8.24±0.16(Predicted)
PSA: 104.45000
LogP: 0.79780

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