An efficient approach toward virantmycin: Stereospecific construction of tetrahydroquinoline ring system employing intramolecular nitrene-addition reaction
An efficient and stereospecific synthesis of the tetrahydroquinoline ring system of the structurally unique alkaloid, virantmycin (1), has been achieved using intramolecular addition reaction of nitrene to olefin as a key step.
Synthetic studies on virantmycin. 1. Total synthesis of (±)-virantmycin and determination of its relative stereochemistry
The efficient and stereospecific route to the tetrahydroquinoline ring models 3 and 4 of virantmycin has been developed by means of an intramolecular nitrene addition reaction as a key step. In the NOE experiments of 4 and 3 we revealed that a ring invers