Synthetic studies on virantmycin. 1. Total synthesis of (±)-virantmycin and determination of its relative stereochemistry
The efficient and stereospecific route to the tetrahydroquinoline ring models 3 and 4 of virantmycin has been developed by means of an intramolecular nitrene addition reaction as a key step. In the NOE experiments of 4 and 3 we revealed that a ring invers