132160-31-7 Usage
Uses
Used in Anticancer Applications:
2-M-HYDROXY PACLITAXEL is used as an anticancer agent for the treatment of patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. It functions as a mitotic inhibitor, disrupting the normal cell division process and thereby inhibiting the growth and proliferation of cancer cells.
Used in Cancer Research:
In the field of cancer research, 2-M-HYDROXY PACLITAXEL is used as a valuable tool for studying the structure and function of microtubules and their interaction with tubulin. This understanding can lead to the development of novel therapeutic strategies and a deeper comprehension of the underlying mechanisms of cancer cell growth and division.
Used in Drug Development:
2-M-HYDROXY PACLITAXEL is also utilized in the development of new drugs and therapies for cancer treatment. Its unique properties and interactions with microtubules make it a promising candidate for the design of novel compounds with improved efficacy and reduced side effects.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-M-HYDROXY PACLITAXEL is used as a key component in the formulation of cancer chemotherapy drugs. Its incorporation into drug formulations can enhance the therapeutic effects and provide patients with more effective treatment options for various types of cancer.
Overall, 2-M-HYDROXY PACLITAXEL is a versatile compound with significant applications in the field of cancer treatment, research, and drug development. Its potential in improving patient outcomes and advancing our understanding of cancer biology makes it a valuable asset in the ongoing fight against this devastating disease.
Check Digit Verification of cas no
The CAS Registry Mumber 132160-31-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,1,6 and 0 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 132160-31:
(8*1)+(7*3)+(6*2)+(5*1)+(4*6)+(3*0)+(2*3)+(1*1)=77
77 % 10 = 7
So 132160-31-7 is a valid CAS Registry Number.
132160-31-7Relevant articles and documents
Synthesis and biological evaluation of 2-acyl analogues of paclitaxel (Taxol)
Kingston, David G. I.,Chaudhary, Ashok G.,Chordia, Mahendra D.,Gharpure, Milind,Gunatilaka, A. A. Leslie,Higgs, Paul I.,Rimoldi, John M.,Samala, Lakshman,Jagtap, Prakash G.,Giannakakou, Paraskevi,Jiang, Yuan Q.,Lin, Chii M.,Hamel, Ernest,Long, Byron H.,Fairchild, Craig R.,Johnston, Kathy A.
, p. 3715 - 3726 (2007/10/03)
The anticancer drug paclitaxel (Taxol) has been converted to a large number of 2-debenzoyl-2-aroyl derivatives by three different methods. The bioactivities of the resulting analogues were determined in both tubulin polymerization and cytotoxicity assays, and several analogues with enhanced activity as compared with paclitaxel were discovered. Correlation of cytotoxicity in three cell lines with tubulin polymerization activity showed reasonable agreement. Among the cell lines examined, the closest correlation with antitubulin activity was observed with a human ovarian carcinoma cell line.
Preparation of phenolic paclitaxel metabolites
Park, Haeil,Hepperle, Michael,Boge, Thomas C.,Himes, Richard H.,Georg, Gunda I.
, p. 2705 - 2709 (2007/10/03)
The synthesis and biological evaluation of the two known phenolic metabolites of paclitaxel are described. The C3'-phenolic metabolite 2 of paclitaxel was prepared from 7-(triethylsilyl)-baccatin III (8) and enantioenriched N-benzoyl-2-azetidinone 7. The C2-phenolic metabolite 3 was synthesized from paclitaxel (1a) via selective C2 debenzoylation and reacylation.
