132274-70-5

Basic information

• Product Name: 1-PHENYL-1H-PYRAZOLE-5-CARBALDEHYDE
• Synonyms: 1-PHENYL-1H-PYRAZOLE-5-CARBALDEHYDE;1-PHENYL-1H-PYRAZOLE-5-CARBOXALDEHYDE;1-phenyl-1H-pyrazole-5-carbaldehyde(SALTDATA: FREE);1-phenyl-1H-pyrazol-5-carbaldehyde;1H-Pyrazole-5-carboxaldehyde, 1-phenyl-;2-phenyl-3-pyrazolecarboxaldehyde;2-phenylpyrazole-3-carbaldehyde
• CAS NO: 132274-70-5
• Molecular Formula: C₁₀H₈N₂O
• Molecular Weight: 172.18
• Product Categories: Heterocycles
• Mol File: 132274-70-5.mol

Chemical Properties

• Melting Point: 31 °C
• Boiling Point: 312.7 °C at 760 mmHg
• Flash Point: 142.9 °C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 0.00052mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.50±0.10(Predicted)
• CAS DataBase Reference: 1-PHENYL-1H-PYRAZOLE-5-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYL-1H-PYRAZOLE-5-CARBALDEHYDE(132274-70-5)
• EPA Substance Registry System: 1-PHENYL-1H-PYRAZOLE-5-CARBALDEHYDE(132274-70-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 24/25
• Hazardous Substances Data: 132274-70-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Phenyl-1h-pyrazole-5-carbaldehyde is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new compounds with therapeutic potential. Its unique structure allows for the creation of molecules that can target specific biological pathways, potentially leading to the discovery of novel treatments for a range of diseases and conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 1-Phenyl-1h-pyrazole-5-carbaldehyde serves as a building block for the synthesis of new agrochemicals, such as pesticides and herbicides. Its reactivity and structural properties enable the design of compounds that can effectively control pests and weeds, thereby enhancing crop protection and contributing to increased agricultural productivity.
Used in Material Science:
1-Phenyl-1h-pyrazole-5-carbaldehyde is utilized in material science for the development of new materials with specific properties. Its incorporation into the molecular structure of these materials can lead to the creation of compounds with unique characteristics, such as improved stability, enhanced reactivity, or novel optical, electronic, or mechanical properties.
Used in Research and Laboratory Settings:
1-Phenyl-1h-pyrazole-5-carbaldehyde may also have potential uses in research and laboratory settings, where it can be employed as a reagent or precursor in various chemical reactions and experiments. Its unique structure and reactivity make it a valuable tool for exploring new chemical pathways and understanding the fundamental principles of organic chemistry.

InChI:InChI=1/C10H8N2O/c13-8-10-6-7-11-12(10)9-4-2-1-3-5-9/h1-8H

Upstream product

• 1126-00-7 1-phenylpyrazole 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1143520-60-8 (1R)-1-(1-naphthalenyl)-N-((1-phenyl-1H-pyrazol-5-yl)methyl)ethanamine 
• 1055244-89-7 4-bromo-1-phenylpyrazole-5-carbaldehyde dimethyl acetal 
• 1055246-96-2 1-phenylpyrazole-5-carbaldehyde dimethyl acetal 
• 132274-75-0 diethyl 1-phenyl-4,5,6,7-tetrahydropyrazolo<4,3-c>pyridazine-4,5-dicarboxylate 
• 132274-74-9 3,8-diphenyl-4,5-dihydro-3H-pyrazolo<4,3-c><1,2,4>triazolo<1,2-a>pyridazine-7,9-dione 
• 132274-72-7 3,7-diphenyl-4,5-dihydropyrrolo<3,4-e>indazole-6,8(7H,8aH)-dione 
• 132274-73-8 1-phenyl-4,5,6,7-tetrahydroindazole-4,4,5,5-tetracarbonitrile 
• 132274-77-2 dimethyl 1-phenylindazole-4,5-dicarboxylate 
• 132274-71-6 dimethyl 6,7-dihydro-1-phenyl-1H-indazole-4,5-dicarboxylate 
• 132274-76-1 dimethyl 1-phenylindazole-4,7-dicarboxylate 
• 137368-90-2 4-[(E)-1-Ethoxycarbonyl-2-(2-phenyl-2H-pyrazol-3-yl)-vinylamino]-1-phenyl-1H-pyrazolo[4,3-c]pyridine-6-carboxylic acid ethyl ester 
• 137368-96-8 (E)-2-[(Z)-1-Ethoxycarbonyl-2-(2-phenyl-2H-pyrazol-3-yl)-vinyliminomethyleneamino]-3-(2-phenyl-2H-pyrazol-3-yl)-acrylic acid ethyl ester 
• 137368-73-1 ethyl β-<(1-phenyl)-5-pyrazolyl>-α-(triphenylphosphoranylidenamino)acrylate 
• 137368-81-1 4-Benzhydryl-1-phenyl-1H-pyrazolo[4,3-c]pyridine-6-carboxylic acid ethyl ester 

Relevant articles and documents

Combination of two pharmacophoric systems: Synthesis and pharmacological evaluation of spirocyclic pyranopyrazoles with high σ1 receptor affinity

The novel class of spirocyclic σ1 ligands 3 (6′,7′-dihydro-1′H-spiro[piperidine-4,4′-pyrano[4,3-c] pyrazoles]) was designed by the combination of the potent σ1 ligands 1 and 2 in one molecule. Thorough structure affinity relationship

Synthesis and structure-affinity relationships of novel spirocyclic σ receptor ligands with furopyrazole structure

The synthesis of novel spirocyclic σ receptor ligands with high affinity is described. The cyclization of the hydroxy acetal 8, which represents a key step in the synthesis of the spirocyclic compounds 3, was supported by theoretical considerations. The a

Spiro-pyrano-pyrazole derivatives

The present invention relates to compounds of formula (I) having pharmacological activity towards the sigma (σ) receptor, and more particularly to some spiro-pyrano-pyrazole derivatives, to processes of preparation of such compounds, to pharmaceutical com

Cycloadditions with 1-Phenyl-5-vinylpyrazole

1-Phenyl-5-vinylpyrazole reacts with dimethylacetylenedicarboxylate (DMAD), N-phenylmaleimide (NPMI), tetracyanoethylene (TCNE), 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD), and diethyl azodicarboxylate (DEAZD) to afford 1:1 adducts through Diels-Alder cyc