132414-06-3

Basic information

• Product Name: 4-(acetylamino)-2,6-dimethylbenzenesulfonyl chloride
• Synonyms: 4-(acetylamino)-2,6-dimethylbenzenesulfonyl chloride
• CAS NO: 132414-06-3
• Molecular Formula: C₁₀H₁₂ClNO₃S
• Molecular Weight: 261.72518
• Mol File: 132414-06-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(acetylamino)-2,6-dimethylbenzenesulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(acetylamino)-2,6-dimethylbenzenesulfonyl chloride(132414-06-3)
• EPA Substance Registry System: 4-(acetylamino)-2,6-dimethylbenzenesulfonyl chloride(132414-06-3)

Safety Data

• Hazardous Substances Data: 132414-06-3(Hazardous Substances Data)

Upstream product

• 108-69-0 3,5-dimethylaminoaniline 
• 2050-45-5 N-acetyl-3,5-dimethylaniline 

Downstream Products

• 64835-50-3 3.5-dimethyl-4-sulfonic acid 
• 67214-70-4 N-(3,5-dimethyl-4-sulfamoylphenyl)-acetamide 
• 132414-07-4 (4-acetamido-2,6-dimethylphenyl)sulfinic acid 
• 132414-03-0 (4-acetamido-2,6-dimethylphenylsulphonyl)nitromethane 
• 67214-71-5 4-amino-2,6-dimethylbenzenesulfonamide 
• 67214-72-6 3,5-Dimethyl-4-sulfamoyl-benzenesulfonyl chloride 

Relevant articles and documents

SUBSTITUTED 2-ANILINOPYRIMIDINES AS CELL CYCLE KINASE INHIBITORS OR RECEPTOR TYROSINE KINASE INHIBITORS, PRODUCTION OF SAID SUBSTANCES AND USE OF THE LATTER AS MEDICAMENTS

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Phenylsulfonylnitromethanes as potent irreversible inhibitors of aldose reductase

Aldose reductase (AR) inhibition provides a viable pharmacologically direct mode for the treatment of diabetic complications. We have synthesized a series of N-4 substituted analogues (15-21) of the known aldose reductase inhibitor phenyl-sulfonylnitromethane. The compounds are potent inhibitors of AR with IC50s between 0.01 and 0.19 μM. Some of the compounds are also potent affinity labels for AR. Compound 19 exhibits the highest and almost complete irreversible inhibition of AR known to date.

AMIDOBENZENE DERIVATIVES, COMPOSITIONS AND USE

The invention concerns novel phenoxy- and phenylthio-acetyl derivatives of (4-amino-2,6-dimethyl-phenylsulphonyl)nitromethane and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example,

ACETAMIDE DERIVATIVES

The invention concerns novel N-phenylacetyl and related acyl derivatives of (4-amino-2,6-dimethylphenylsulphonyl)nitromethane and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example,i

AMIDE DERIVATIVES, COMPOSITIONS AND USE

The invention concerns novel (oxamido- and ureido-phenylsulfonyl)nitromethane derivatives and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain peripher