132663-51-5

Basic information

• Product Name: 2-nitrobenzyl propanoate
• Synonyms: 2-Nitrobenzenemethanol propionate; 2-Nitrobenzyl propionate; benzenemethanol, 2-nitro-, propanoate (ester)
• CAS NO: 132663-51-5
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.1986
• Mol File: 132663-51-5.mol

Chemical Properties

• Boiling Point: 295.8°C at 760 mmHg
• Flash Point: 126.1°C
• Density: 1.226g/cm³
• Vapor Pressure: 0.00149mmHg at 25°C
• Refractive Index: 1.538
• CAS DataBase Reference: 2-nitrobenzyl propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-nitrobenzyl propanoate(132663-51-5)
• EPA Substance Registry System: 2-nitrobenzyl propanoate(132663-51-5)

Safety Data

• Hazardous Substances Data: 132663-51-5(Hazardous Substances Data)

Upstream product

• 612-23-7 2-nitrobenzyl chloride 
• 802294-64-0 propionic acid 
• 72-03-7 propanoate 
• 3958-60-9 2-nitrophenylmethyl bromide 

Relevant articles and documents

Facile construction of thermo-responsive Pickering emulsion for esterification reaction in phase transfer catalysis system

In this paper, a thermo-responsive Pickering emulsion (PE) is constructed for the esterification reaction in the phase transfer catalysis (PTC) system. Silica nanoparticle modified by alkyl polyoxyethylene ether and tetrabutylammonium bromide (TBAB) is the highly efficient thermo-responsive Pickering emulsifier to stabilize the diisopropyl ketone-in-water emulsion. PEs can keep stable at room temperature for 3 days and demulsify only in the condition of elevated temperature and agitation, which causes the easy product separation and aqueous phase recycling. The adsorption of TBA+ and nonionic surfactant via electrostatic interaction and hydrogen bonding, respectively, can increase the hydrophobicity and the emulsifying capacity of silica nanoparticle. The ion-pair of TBA+ and reactant anion is generated and can be transferred into the organic phase, initiating the bond-forming reaction. The modifying effect of polyoxyethylene ether is weakened with the increase of temperature due to the loss of the hydrogen bonding interaction, resulting in the demulsification of PEs. Moreover, the cloud point of polyoxyethylene ether is the temperature for the complete separation of two phases. In this PTC system, the conversion rate for the esterification can reach to 92 % and the aqueous phase can be reused at least 5 times without sacrifice of the catalytic activity, demonstrating the potential application in industry.

Nitrobenzyl esters as potential conjugated alkylating and differentiation promoting agents: Antitumor effect in vivo

A series of ortho and para-nitrobenzyl esters of short chain fatty acids (C2 to C5) and of the lipophilic aminoacid, L-valine, and some other o-nitrobenzylated products were prepared. Bioreductive or hydrolytic cleavages of these compounds could release both differentiation promoting agents such as butyric acid and electrophilic moieties able to alkylate DNA. The antitumor effects of these compounds, either alone and/or associated with an immunostimulating agent (corynebacterium parvum, CP) or interferon (IFN) treatment, was studied using the 180 TG Crocker Sarcoma grafted onto Swiss mice. Based on the mean survival time and the final survival rate, the most active compounds used alone were the o-nitrobenzyl acetate and the 0-nitrobenzyl butyrate. Previous stimulation of the immune competent cells by CP before antitumor treatment increased the efficiency of most of the nitrobenzylated derivatives studied. The association with IFN did not significantly improve the antitumor effect.