13297-36-4Relevant articles and documents
Cobalt-Catalyzed Sustainable Synthesis of Benzimidazoles by Redox-Economical Coupling of o-Nitroanilines and Alcohols
Das, Sanju,Mallick, Samrat,De Sarkar, Suman
, p. 12111 - 12119 (2019/10/02)
This study reveals cobalt-catalyzed sustainable synthesis of benzimidazoles by redox-economical coupling of o-nitroanilines and alcohols. The major advantage of this report is the use of a commercially available cheap cobalt catalyst to produce a wide variety of 2-substituted benzimidazoles by hydrogen autotransfer without using any additional external redox reagent and costly ligand system. A thorough mechanistic insight of the reaction is proposed by performing a series of control experiments.
Lithiation and Side-Chain Substitution of 3-Alkyl-1H-quinoxalin-2-ones
Smith, Keith,El-Hiti, Gamal A.,Mahgoub, Safaa A.
, p. 2345 - 2348 (2007/10/03)
3-Methyl-1H-quinoxalin-2-one has been doubly lithiated with n-butylithium at -78° C in THF. The dilithio reagent thus obtained reacts with various electrophiles (iodomethane, iodoethane, D2O, benzaldehyde, benzophenone, cyclohexanone) to give modified 3-substituted 1H-quinoxalin-2- ones in good yields. In the reaction of the dilithio reagent with phenyl isothiocyanate the product was a tautomer of the simple substitution product. Reaction of the dilithio reagent with iodine gives an oxidatively dimerised product instead of the 3-iodomethyl derivative. Lithiations of 3-ethyl-and 3-propyl-1H-quinoxalin-2-ones, followed by reactions with representative electrophiles (benzaldehyde, benzophenone, cyclohexanone), behaved in a similar manner to give the corresponding modified 3-substituted derivatives in good yields.
Design, synthesis, and biological activities of new thieno[3,2- d]pyrimidines as selective type 4 phosphodiesterase inhibitors
Crespo, Maria I.,Pagès, Lluís,Vega, Armando,Segarra, Victor,López, Manel,Doménech, Teresa,Miralpeix, Montserrat,Beleta, Jordi,Ryder, Hamish,Palacios, José M.
, p. 4021 - 4035 (2007/10/03)
A common pharmacophore for compounds structurally related to nitraquazone has been derived. Using this pharmacophore, new structures have been designed, synthesized, and evaluated for their inhibitory potencies against cyclic adenosine 5'-monophosphate (c
