Unsymmetrical Diarylketones from Electron-rich Heterocyclic Arenes
AlCl3-mediated chlorocarbonylation of a first arene by oxalyl chloride followed by in situ Friedel-Crafts acylation of a second electron-rich arene expeditiously provides, in a one-pot procedure, either symmetrical or unsymmetrical benzophenones with yields ranging from 17-52%. Best results are obtained when the more activated substrate is used as the second arene. Another advantage is that the resultant benzophenone precipitates from the reaction mixture allowing facile workup.
Poupaert, Jacques H.,Depreux, Patrick,McCurdy, Christopher R.
New imidazole derivatives of 2(3H)-benzazolones as potential antifungal agents
A series of new imidazole derivatives containing 2(3H)-benzoxazolone or 2(3H)-benzothiazolone ring were synthesized as analogues of the antifungal drug bifonazole. All compounds were tested in vitro against Candida albicans, Candida parapsilosis, and Cand
The invention concerns the use of a compound of formula (I) inhibitor of aromatase for the preparation of a pharmaceutical formulation intended for treatment of cancer or psoriasis. It equally relates to compounds of formula (I), notably for their use as active ingredients of a medication.
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Page/Page column 4
(2010/11/26)
AlCl3-DMF Reagent in the Friedel-Crafts Reaction. Application to the Acylation Reaction of 2(3H)-Benzothiazolones
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Yous, Said,Poupaert, Jacques H.,Lesieur, Isabelle,Depreux, Patric,Lesieur, Daniel
p. 1574 - 1576
(2007/10/02)
Benzothiazolinone compounds
Compounds of general formula (I): STR1 in which: R1 represents a hydrogen atom or a lower alkyl group, R2 represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstitute
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(2008/06/13)
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