- Colorimetric 'naked-eye' sensor for anions based on conformational flexible tripodal receptor
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A new tripodal receptor for anion sensing based on amide-pyridinium as recognition site and nitro-benzene as signaling unit was designed and successfully synthesized. This receptor showed high selectivity and strong binding affinity toward AcO-
- Bao, Shuang,Gong, Wei-Tao,Chen, Wen-Dan,Ye, Jun-Wei,Lin, Yuan,Ning, Gui-Ling
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Read Online
- Spectroscopic and Crystallographic Characterization of the R3N+?C?H???X Interaction
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As appreciation for nonclassical hydrogen bonds has progressively increased, so have efforts to characterize these interesting interactions. Whereas several kinds of C?H hydrogen bonds have been well-studied, much less is known about the R3Nsu
- Capilato, Joseph N.,Harry, Stefan A.,Lectka, Thomas,Siegler, Maxime A.
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- N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2)
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A series of 23 N-(Pyridin-3-yl)benzamides was synthesized and evaluated for their potential to inhibit human steroid-11β-hydroxylase (CYP11B1) and human aldosterone synthase (CYP11B2). The most potent and selective CYP11B2 inhibitors (IC50 valu
- Zimmer, Christina,Hafner, Marieke,Zender, Michael,Ammann, Dominic,Hartmann, Rolf W.,Vock, Carsten A.
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supporting information; experimental part
p. 186 - 190
(2011/02/25)
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- Exploration of secondary and tertiary pharmacophores in unsymmetrical N,N′-diaryl urea inhibitors of soluble epoxide hydrolase
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The impact of various secondary and tertiary pharmacophores on in vitro potency of soluble epoxide hydrolase (sEH) inhibitors based on the unsymmetrical urea scaffold 1 is discussed. N,N′-Diaryl urea inhibitors of soluble epoxide hydrolase exhibit subtle variations in inhibitory potency depending on the secondary pharmacophore but tolerate considerable structural variation in the second linker/tertiary pharmacophore fragment.
- Anandan, Sampath-Kumar,Gless, Richard D.
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scheme or table
p. 2740 - 2744
(2010/07/15)
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- Substituted cyclic amine compound, production process thereof and pharmaceutical composition for circulatory organ use containing the same
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A substituted cyclic amine compound represented by the following general formula (1) STR1 wherein each of R1 to R5 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or the like, A represents a carbonyl group or a sulfonyl group, B represents a methine moiety or a nitrogen atom, D represents a methine moiety, a nitrogen atom or =N(→O)-- and n is an integer of 2 to 3; and synthetic methods thereof. The inventive compound is useful in preventing and treating circulatory organ-related diseases such as hypertension, ischemic heart disease, cerebrovascular disease, peripheral circulatory disease and the like.
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- Towards the development of non-enediyne approaches for mimicking enediyne chemistry: Design, synthesis and activity of a 1,4-bisdiazonium compound
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1,4-bisdiazonium compounds, whichmay be precursors of aryl 1,4-diradicals, have the potential to mimic the DNA cleaving activity of the enediyne antibiotics. To this end, the ability to generate and activate 1,4-bisdiazonium compounds in good yield (e.g.,
- Arya, Dev P.,Jebaratnam, David J.
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p. 4369 - 4372
(2007/10/02)
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