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133180-01-5

Fmoc-O-trityl-L-threonine, also known as Fmoc-Trt-Thr-OH, is a protected amino acid derivative used in the field of peptide synthesis. It is characterized by the presence of the 9-fluorenylmethoxycarbonyl (Fmoc) group, which serves as a protecting group for the amino group, and the trityl (Trt) group, which protects the hydroxyl group of the threonine side chain. This derivative allows for selective modification of the side-chain hydroxyl group while the peptide is attached to the solid support, making it an excellent choice for the synthesis of phosphothreonine-containing peptides and peptides with modifications at the threonine side chain. Fmoc-O-trityl-L-threonine is a white to off-white crystalline powder and is known to produce purer products compared to standard t-Bu protected amino acids.

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  • 133180-01-5 Structure

  • Basic information

    1. Product Name: Fmoc-O-trityl-L-threonine
    2. Synonyms: N-ALPHA-FMOC-O-TRITYL-L-THREONINE;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-TRITYL-L-THREONINE;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-TRITYL-L-THREONINE;TRITYL-L-THREONINE;FMOC-L-THR(TRT)-OH;FMOC-O-TRITYL-L-THREONINE;FMOC-THR(TRT);FMOC-THR(TRT)-OH
    3. CAS NO:133180-01-5
    4. Molecular Formula: C38H33NO5
    5. Molecular Weight: 583.67
    6. EINECS: N/A
    7. Product Categories: Amino Acids;Threonine [Thr, T];Fmoc-Amino Acids and Derivatives;Fmoc-Amino acid series
    8. Mol File: 133180-01-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 753 °C at 760 mmHg
    3. Flash Point: 409.2 °C
    4. Appearance: /
    5. Density: 1.241 g/cm3
    6. Vapor Pressure: 7.95E-24mmHg at 25°C
    7. Refractive Index: 1.632
    8. Storage Temp.: -20°C
    9. Solubility: N/A
    10. PKA: 3.31±0.10(Predicted)
    11. CAS DataBase Reference: Fmoc-O-trityl-L-threonine(CAS DataBase Reference)
    12. NIST Chemistry Reference: Fmoc-O-trityl-L-threonine(133180-01-5)
    13. EPA Substance Registry System: Fmoc-O-trityl-L-threonine(133180-01-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 133180-01-5(Hazardous Substances Data)

133180-01-5 Usage

Uses

Used in Pharmaceutical Industry:
Fmoc-O-trityl-L-threonine is used as a building block for the synthesis of various peptides and peptide-based drugs. Its selective protection of the amino and hydroxyl groups allows for the controlled assembly of complex peptide structures, which are essential in the development of therapeutic agents for a wide range of diseases.
Used in Research and Development:
In the field of research, Fmoc-O-trityl-L-threonine is utilized as a key component in the synthesis of novel peptides and peptidomimetics. Its unique properties enable the exploration of new peptide sequences and modifications, contributing to the advancement of peptide-based research and the discovery of new bioactive molecules.
Used in Chemical Synthesis:
Fmoc-O-trityl-L-threonine is employed as a protected amino acid in various chemical synthesis processes. Its selective protection of functional groups allows for the controlled formation of peptide bonds and the introduction of specific modifications, making it a valuable tool in the synthesis of complex organic molecules and materials.
Used in Drug Delivery Systems:
In the development of drug delivery systems, Fmoc-O-trityl-L-threonine can be used to synthesize peptide-based carriers or targeting moieties. These modified peptides can enhance the delivery, bioavailability, and therapeutic outcomes of various drugs, particularly in the context of cancer treatment and other diseases.
Overall, Fmoc-O-trityl-L-threonine is a versatile and valuable compound in the fields of pharmaceuticals, research and development, chemical synthesis, and drug delivery systems, playing a crucial role in the synthesis and modification of peptides and peptide-based therapeutics.

Check Digit Verification of cas no

The CAS Registry Mumber 133180-01-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,1,8 and 0 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 133180-01:
(8*1)+(7*3)+(6*3)+(5*1)+(4*8)+(3*0)+(2*0)+(1*1)=85
85 % 10 = 5
So 133180-01-5 is a valid CAS Registry Number.
InChI:InChI=1/C38H33NO5/c1-26(44-38(27-15-5-2-6-16-27,28-17-7-3-8-18-28)29-19-9-4-10-20-29)35(36(40)41)39-37(42)43-25-34-32-23-13-11-21-30(32)31-22-12-14-24-33(31)34/h2-24,26,34-35H,25H2,1H3,(H,39,42)(H,40,41)/t26-,35+/m1/s1

133180-01-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S,3R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-trityloxybutanoic acid

1.2 Other means of identification

Product number -
Other names N-Fmoc-O-trityl-threonine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:133180-01-5 SDS

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