- Synthesis of dibenzo[def,p]chrysene, its active metabolites, and their 13C-labeled analogues
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Dibenzo[def,p]chrysene (DBC) Is a highly carcinogenic polycyclic aromatic hydrocarbon suspected to be Involved in initiation of lung cancer in smokers. Efficient new syntheses of DBC, Its active metabolites [DBC diol (1), DBC dione (2), DBC diol epoxlde (3)], and their previously unknown 13C 2-labeled analogues are reported. The 13C 2-labeled analogues are required as standards for sensitive methods of analysis of their DNA adducts in human cells using stable isotope dilution liquid chromatography/tandem mass spectrometry.
- Xu, Daiwang,Duan, Yazhen,Blair, Ian A.,Penning, Trevor M.,Harvey, Ronald G.
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supporting information; experimental part
p. 1059 - 1062
(2009/04/06)
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