133276-80-9

Basic information

• Product Name: Samixogrel
• Synonyms: Samixogrel;6-(4-(2-(((4-chlorophenyl)sulfonyl)amino)ethyl)phenyl)-6-(3-pyridyl)hex-5-enoic acid
• CAS NO: 133276-80-9
• Molecular Formula: C₂₅H₂₅ClN₂O₄S
• Molecular Weight: 484.99
• Mol File: 133276-80-9.mol

Chemical Properties

• Boiling Point: 704.9°Cat760mmHg
• Flash Point: 380.1°C
• Appearance: /
• Density: 1.296g/cm³
• Vapor Pressure: 7.43E-21mmHg at 25°C
• Refractive Index: 1.609
• PKA: 4.66±0.10(Predicted)
• CAS DataBase Reference: Samixogrel(CAS DataBase Reference)
• NIST Chemistry Reference: Samixogrel(133276-80-9)
• EPA Substance Registry System: Samixogrel(133276-80-9)

Safety Data

• Hazardous Substances Data: 133276-80-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C25H25ClN2O4S/c26-22-11-13-23(14-12-22)33(31,32)28-17-15-19-7-9-20(10-8-19)24(5-1-2-6-25(29)30)21-4-3-16-27-18-21/h3-5,7-14,16,18,28H,1-2,6,15,17H2,(H,29,30)/b24-5+

Upstream product

• 877-95-2 methyl-N-(benzyl-methyl)-formamide 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 20260-53-1 pyridine-3-carbonyl chloride hydrochloride 
• 17814-85-6 (4-carboxybutyl)triphenylphosphonium bromide 
• 133276-83-2 4-(2-(((4-chlorophenyl)sulfonyl)amino)ethyl)phenyl 3-pyridyl ketone 

Downstream Products

• 153732-13-9 (E)-methyl 6-[4-(2-{[(4-chlorophenyl)sulfonyl]amino}ethyl)phenyl]-6-( 3-pyridyl)hex-5-enoate 
• 133276-60-5 6-(4-(2-(4-chlorobenzenesulphonylamino)ethyl)-phenyl)-6-(3-pyridyl)hexanoic acid 
• 1027887-70-2 (E)-6-(4-{2-[(4-Chloro-benzenesulfonyl)-methyl-amino]-ethyl}-phenyl)-6-pyridin-3-yl-hex-5-enoic acid methyl ester 
• 1027149-72-9 (E)-6-(4-{2-[(4-Chloro-benzenesulfonyl)-ethyl-amino]-ethyl}-phenyl)-6-pyridin-3-yl-hex-5-enoic acid methyl ester 
• 1027268-52-5 (E)-6-(4-{2-[(4-Chloro-benzenesulfonyl)-isopropyl-amino]-ethyl}-phenyl)-6-pyridin-3-yl-hex-5-enoic acid methyl ester 
• 1027480-77-8 (E)-6-(4-{2-[Carbamoylmethyl-(4-chloro-benzenesulfonyl)-amino]-ethyl}-phenyl)-6-pyridin-3-yl-hex-5-enoic acid methyl ester 
• 1026390-24-8 (E)-6-(4-{2-[Benzyl-(4-chloro-benzenesulfonyl)-amino]-ethyl}-phenyl)-6-pyridin-3-yl-hex-5-enoic acid methyl ester 
• 1027301-52-5 (E)-6-(4-{2-[tert-Butoxycarbonylmethyl-(4-chloro-benzenesulfonyl)-amino]-ethyl}-phenyl)-6-pyridin-3-yl-hex-5-enoic acid methyl ester 
• 1026644-87-0 (E)-6-(4-{2-[(4-Chloro-benzenesulfonyl)-(2-morpholin-4-yl-ethyl)-amino]-ethyl}-phenyl)-6-pyridin-3-yl-hex-5-enoic acid methyl ester 

Relevant articles and documents

Arylsulphonamides pharmaceutical compositions containing these compounds

The invention relates to new arylsulphonamides of the formula STR1 (wherein A, B and R1 to R6 are as defined in claim 1, the enantiomers, the cis- and trans-isomers thereof where R4 and R5 together represent a c

6,6-Disubstituted hex-5-enoic acid derivatives as combined thromboxane A2 receptor antagonists and synthetase inhibitors

A series of ω-disubstituted alkenoic acid derivatives were designed and synthesized as antithrombotic inhibitors of thromboxane A2 synthetase and thromboxane A2 receptor antagonists. Hexenoic acid derivatives with a 3- pyridyl group