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98-60-2

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98-60-2 Usage

Chemical Properties

white to light yellow crystals, powder or flakes

Uses

4-Chlorobenzenesulfonyl chloride was used in the synthesis of precursors for the 3,4-pyridyne generation.

Synthesis Reference(s)

The Journal of Organic Chemistry, 7, p. 15, 1942 DOI: 10.1021/jo01195a003

Purification Methods

Crystallise it from ether in powdered Dry-Ice, after the solution has been washed with 10% NaOH until colourless and dried (Na2SO4). Distil it in vacuo and store it in the absence of H2O. [Beilstein 11 IV 114.]

Check Digit Verification of cas no

The CAS Registry Mumber 98-60-2 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 8 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 98-60:
(4*9)+(3*8)+(2*6)+(1*0)=72
72 % 10 = 2
So 98-60-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H4Cl2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H

98-60-2 Well-known Company Product Price

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  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A10271)  4-Chlorobenzenesulfonyl chloride, 97%   

  • 98-60-2

  • 100g

  • 291.0CNY

  • Detail
  • Alfa Aesar

  • (A10271)  4-Chlorobenzenesulfonyl chloride, 97%   

  • 98-60-2

  • 500g

  • 955.0CNY

  • Detail
  • Alfa Aesar

  • (A10271)  4-Chlorobenzenesulfonyl chloride, 97%   

  • 98-60-2

  • 2500g

  • 3817.0CNY

  • Detail
  • Aldrich

  • (133698)  4-Chlorobenzenesulfonylchloride  97%

  • 98-60-2

  • 133698-5G

  • 253.89CNY

  • Detail
  • Aldrich

  • (133698)  4-Chlorobenzenesulfonylchloride  97%

  • 98-60-2

  • 133698-100G

  • 560.43CNY

  • Detail
  • Aldrich

  • (133698)  4-Chlorobenzenesulfonylchloride  97%

  • 98-60-2

  • 133698-500G

  • 1,807.65CNY

  • Detail

98-60-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Chlorobenzenesulfonyl chloride

1.2 Other means of identification

Product number -
Other names 4-Chlorobenzene-1-sulfonyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:98-60-2 SDS

98-60-2Relevant articles and documents

Facile synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazides

Chen, Rongxiang,Xu, Shaohong,Shen, Fumin,Xu, Canran,Wang, Kaikai,Wang, Zhanyong,Liu, Lantao

, (2021/09/20)

A simple and rapid method for efficient synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazide with NXS (X = Cl or Br) and late-stage conversion to several other functional groups was described. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides and sulfonates. In most cases, these reactions are highly selective, simple, and clean, affording products at excellent yields.

Preparation method of medical intermediate of parachlorobenzenesulfonyl chloride

-

Page/Page column 4-6, (2019/03/08)

The invention discloses a preparation method of a medical intermediate of parachlorobenzenesulfonyl chloride. The preparation method specifically comprises the following steps: firstly, cyclodextrin is modified sequentially through maleic anhydride and tetradecyl trimethyl ammonium chloride, and the modified cyclodextrin is obtained; and then a reaction is conducted by adopting sodium 4-chlorobenzenesulfonate and thionyl chloride as raw materials and the modified cyclodextrin as a catalyst, and by being added with ammonium trifluoroacetate for assisting. The prepared medical intermediate of the parachlorobenzenesulfonyl chloride is high in yield and high in purity, the reacting conditions are easy to operate, the requirements for equipment are low, and control is easy.

Design, synthesis and biological evaluation of novel phenylsulfonylurea derivatives as PI3K/mTOR dual inhibitors

Zhao, Bingbing,Lei, Fei,Wang, Caolin,Zhang, Binliang,Yang, Zunhua,Li, Wei,Zhu, Wufu,Xu, Shan

, (2018/07/13)

Five series of novel phenylsulfonylurea derivatives, 19a–d, 20a–d, 21a–d, 22a–d and 23a–d, bearing 4-phenylaminoquinoline scaffold were designed, synthesized and their IC50 values against four cancer cell lines (HepG-2, A549, PC-3 and MCF-7) were evaluated. Most compounds showed moderate cytotoxicity activity against the cancer cell lines. Structure–activity relationships (SARs) and pharmacological results indicated that introduction of 4-aminoquinoline scaffold and phenylsulfonylurea scaffold were beneficial for anti-tumor activity. Moreover, para-methoxyl substitution of 4-anilino moiety and para-halogen substitution of phenylsulfonylurea have different impacts on different series of compounds. Furthermore, the micromolecule group substitution in the 6-position of the quinoline ring have a slight impact on the cellular activity of the target compounds.

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