1333866-93-5 Usage
Uses
Used in Pharmaceutical Research and Drug Development:
(3'-Chloro-5'-trifluoroMethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3-yl)-carbaMic acid tert-butyl ester is used as a potential target for new drug candidates in pharmaceutical research and drug development. Its unique structure and potential biological activity make it a promising candidate for further investigation and development.
Used as an Intermediate in Organic Synthesis:
(3'-Chloro-5'-trifluoroMethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3-yl)-carbaMic acid tert-butyl ester is also utilized as an intermediate in organic synthesis, where its complex structure and functional groups can be further modified or used to create more complex molecules with specific applications.
Used as a Reference Compound in Analytical Chemistry:
Due to its distinct structure and properties, (3'-Chloro-5'-trifluoroMethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3-yl)-carbaMic acid tert-butyl ester serves as a reference compound in analytical chemistry. It can be used to calibrate instruments, validate analytical methods, or as a standard for comparison in various chemical analyses.
Ongoing Research:
Further research on the properties and potential applications of (3'-Chloro-5'-trifluoroMethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3-yl)-carbaMic acid tert-butyl ester is necessary to fully understand its capabilities and maximize its utility in various industries. This research may lead to new discoveries and applications in fields such as medicine, materials science, and environmental science.
Check Digit Verification of cas no
The CAS Registry Mumber 1333866-93-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,3,8,6 and 6 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1333866-93:
(9*1)+(8*3)+(7*3)+(6*3)+(5*8)+(4*6)+(3*6)+(2*9)+(1*3)=175
175 % 10 = 5
So 1333866-93-5 is a valid CAS Registry Number.
1333866-93-5Relevant articles and documents
HETEROCYCLIC DERIVATIVES AS Nav1.7 and Nav1.8 BLOCKERS
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Paragraph 0153, (2020/07/15)
The present invention relates to heterocyclic derivatives which have blocking activities of voltage gated sodium channels as the Nav1.7 and Nav1.8 channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gat
Discovery and optimization of selective and in vivo active inhibitors of the lysophosphatidylserine lipase α/β-hydrolase domain-containing 12 (ABHD12)
Ogasawara, Daisuke,Ichu, Taka-Aki,Jing, Hui,Hulce, Jonathan J.,Reed, Alex,Ulanovskaya, Olesya A.,Cravatt, Benjamin F.
, p. 1643 - 1656 (2019/02/19)
ABHD12 is a membrane-bound hydrolytic enzyme that acts on the lysophosphatidylserine (lyso-PS) and lysophosphatidylinositol (lyso-PI) classes of immunomodulatory lipids. Human and mouse genetic studies point to a key role for the ABHD12-(lyso)-PS/PI pathway in regulating (neuro)immunological functions in both the central nervous system and periphery. Selective inhibitors of ABHD12 would offer valuable pharmacological probes to complement genetic models of ABHD12-regulated (lyso)-PS/PI metabolism and signaling. Here, we provide a detailed description of the discovery and activity-based protein profiling (ABPP) guided optimization of reversible thiourea inhibitors of ABHD12 that culminated in the identification of DO264 as a potent, selective, and in vivo active ABHD12 inhibitor. We also show that DO264, but not a structurally related inactive control probe (S)-DO271, augments inflammatory cytokine production from human THP-1 macrophage cells. The in vitro and in vivo properties of DO264 designate this compound as a suitable chemical probe for studying the biological functions of ABHD12-(lyso)-PS/PI pathways.
