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Desfluoro Iloperidone (IMpurity) is an analog of Iloperidone (I267200), which is a compound with potential applications in the pharmaceutical industry due to its anti-psychotic properties. As an impurity in the synthesis of Iloperidone (I267200), Desfluoro Iloperidone (IMpurity) may have implications for the development and efficacy of anti-psychotic medications.

133454-46-3

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133454-46-3 Usage

Uses

Used in Pharmaceutical Industry:
Desfluoro Iloperidone (IMpurity) is used as a research compound for understanding the anti-psychotic profile of Iloperidone (I267200). This knowledge can contribute to the development of more effective treatments for psychological disorders, primarily schizophrenia in adults.
Used in Drug Synthesis:
Desfluoro Iloperidone (IMpurity) plays a role in the synthesis process of Iloperidone (I267200), which is an important anti-psychotic medication. By studying and managing the presence of this impurity, researchers and pharmaceutical companies can improve the quality and efficacy of the final drug product.
Used in Quality Control:
Desfluoro Iloperidone (IMpurity) is used as a reference material in quality control processes for the production of Iloperidone (I267200). By monitoring and controlling the levels of this impurity, manufacturers can ensure the safety and effectiveness of the final drug product.

Check Digit Verification of cas no

The CAS Registry Mumber 133454-46-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,4,5 and 4 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 133454-46:
(8*1)+(7*3)+(6*3)+(5*4)+(4*5)+(3*4)+(2*4)+(1*6)=113
113 % 10 = 3
So 133454-46-3 is a valid CAS Registry Number.

133454-46-3Downstream Products

133454-46-3Relevant articles and documents

Improved and efficient process for the production of highly pure iloperidone: A psychotropic agent

Solanki, Pavankumar V.,Uppelli, Sekhar Babu,Pandit, Bhushan S.,Mathad, Vijayavitthal T.

, p. 342 - 348 (2014/03/21)

The present work describes an improved and highly efficient process for the synthesis of iloperidone (1), an antipsychotic agent, which is free from potential impurities. The synthesis comprises N-alkylation of 1-(4-(3-chloropropoxy)-3-methoxyphenyl)ethanone (4) with 6-fluoro-3-piperidin-4- yl-1,2-benzisoxazole hydrochloride (5) in a mixture of water and heptane as solvent and sodium hydroxide as a base in the presence of tetrabutylammonium bromide as a phase transfer catalyst to yield iloperidone (1) with a yield of around 95% and a purity of 99.80% by HPLC. The present work also describes the optimization details performed to achieve the process attributes responsible for high yield and purity.

3-(heteroaryl)-1-?(2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1-?(2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility

-

, (2008/06/13)

Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.

1-(arylthioalkyl, arylaminoalkyl or arylmethylenealkyl)-4-(heteroaryl) piperidines and related compounds useful as antipsychotics and analgesics

-

, (2008/06/13)

Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.

3-[[(Aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: Antipsychotic profile of iloperidone (HP 873)

Strupczewski,Bordeau,Chiang,Glamkowski,Conway,Corbett,Hartman,Szewczak,Wilmot,Helsley

, p. 1119 - 1131 (2007/10/02)

A series of 3-[[(aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles was synthesized and evaluated as potential antipsychotic D2/5-HT2 antagonists. Most of these compounds showed potent antipsychotic-like activity in an apomorphine-induced

Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics

-

, (2008/06/13)

Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.

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