133614-04-7

Basic information

• Product Name: 2-Propen-1-one,1-(3-pyridinyl)-(9CI)
• Synonyms: 2-Propen-1-one,1-(3-pyridinyl)-(9CI);1-(3-pyridinyl)-2-Propen-1-one
• CAS NO: 133614-04-7
• Molecular Formula: C₈H₇NO
• Molecular Weight: 133.14728
• Product Categories: PYRIDINE
• Mol File: 133614-04-7.mol

Chemical Properties

• Boiling Point: 229.7±22.0 °C(Predicted)
• Appearance: /
• Density: 1.058±0.06 g/cm3(Predicted)
• PKA: 2.98±0.10(Predicted)
• CAS DataBase Reference: 2-Propen-1-one,1-(3-pyridinyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one,1-(3-pyridinyl)-(9CI)(133614-04-7)
• EPA Substance Registry System: 2-Propen-1-one,1-(3-pyridinyl)-(9CI)(133614-04-7)

Safety Data

• Hazardous Substances Data: 133614-04-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Propen-1-one,1-(3-pyridinyl)-(9CI) is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of medicinal compounds.
Used in Pesticide Industry:
In the pesticide industry, 2-Propen-1-one,1-(3-pyridinyl)-(9CI) is used as a component in the formulation of pesticides, leveraging its chemical properties to enhance the effectiveness of these products.
Used in Food and Beverage Industry:
2-Propen-1-one,1-(3-pyridinyl)-(9CI) is used as a flavoring agent and fragrance in the food and beverage industry, adding unique taste and aroma profiles to various products.
Used in Industrial Products:
2-Propen-1-one,1-(3-pyridinyl)-(9CI) is also utilized in the production of other industrial products, where its chemical properties are harnessed to improve the performance or characteristics of the final product.

Upstream product

• 1826-67-1 vinyl magnesium bromide 
• 95091-91-1 N-methoxy-N-methylpyridine-3-carboxamide 
• 144825-44-5 (+/-)-tert-butyl 1-(pyridin-3'-yl)prop-2-en-1-yl carbonate 
• 350-03-8 methyl-3-pyridylketone 
• 50-00-0 formaldehyd 
• 1570-48-5 1-(pyridin-3-yl)propan-1-one 

Downstream Products

• 1239469-77-2 C₂₇H₂₈N₂O₃ 
• 867215-90-5 3-(2-(3-(2,6-dichlorophenyl)isoxazol-5-yl)pyridin-4-ylamino)-1-(pyridin-3-yl)propan-1-one 

Relevant articles and documents

Synthesis of 4-Acylpyrazoles from Saturated Ketones and Hydrazones Featured with Multiple C(sp3)-H Bond Functionalization and C-C Bond Cleavage and Reorganization

In this paper, an efficient and convenient one-pot synthesis of diversely substituted 4-acylpyrazole derivatives via copper-catalyzed one-pot cascade reactions of saturated ketones with hydrazones is reported. Mechanistically, the formation of the title compounds involves the in situ formation of an enone intermediate through the dehydrogenation of a saturated ketone and the [2 + 3] cyclization of the enone with hydrazone followed by an aromatization-driven C-C bond cleavage and reorganization. To our knowledge, this is the first example in which the biologically and pharmaceutically important yet otherwise difficult-to-obtain 4-acylpyrazole derivatives are directly prepared from saturated ketones and hydrazones featured with multiple aliphatic C-H bond functionalization and C-C bond cleavage and reorganization. Compared with literature methods, this novel process has advantages such as simple and economical starting materials, a sustainable oxidant, excellent regioselectivity, and good efficiency.

New pyridin-3-ylmethyl carbamodithioic esters activate pyruvate kinase M2 and potential anticancer lead compounds

Pyruvate kinase M2 (PKM2) is a key protein responsible for cancer's Warburg effect. Activation of PKM2 may alter aberrant metabolism in cancer cells, which suggests PKM2 as a tumor selective therapeutic target. In this paper, the lead compound 8 was first discovered as a new kind of PKM2 activator from a random screening of an in-house compound library. Then, a series of lead compound 8 analogs were designed, synthesized and evaluated for their activation of PKM2 and anticancer activities. 7-Azaindole analog 32 was identified as the most potent PKM2 activator. Compounds with potent enzyme activity also exhibited selective anti-proliferation activity on cancer cell lines HCT116, Hela and H1299 compared with non-tumor cell line BEAS-2B. The structure-activity relationships of these compounds were supported by molecular docking results. Preliminary pharmacological studies also showed that compound 32 arrests the cell cycle at the G2/M phase in HCT116 cell line.

Access to the nicotine system by application of a guanidine-catalyzed asymmetric Michael addition of diphenyliminoacetate with 3-pyridyl vinyl ketone

A guanidine-based chiral organocatalyst was successfully applied to the Michael addition of diphenyliminoacetate to pyridyl vinyl ketone as a key reaction for the construction of the nicotine system.

HETEROCYCLIC ANTI-VIRAL COMPOUNDS COMPRISING METABOLIZABLE MOIETIES AND THEIR USES

The present invention relates to substituted prodrug and compositions thereof useful for treating or preventing Hepatitis C virus (HCV) infections. In particular, the present invention relates to prodrugs of substituted diphenyl-, diheteroaryl- and mixed phenyl heteroaryl substituted five-membered heterocycle compounds, compositions comprising the compounds and the use of such compounds and compositions to inhibit HCV replication and/or proliferation as a therapeutic approach towards the treatment and/or prevention of HCV infections in humans and animals.

2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists

The present invention is directed to a specifically substituted tetrahydrofuran of the formula (I) STR1 wherein Ar is a pyridyl, dimethoxy-pyridyl or a dimethoxy-pyrazinyl group, R4 is an alkylthio, alkylsulfinyl or alkylsulfonyl containing gro