- VINYL DERIVATIVES OF HETEROCYCLIC SYSTEMS AND THEIR POLIMERS: 3-VINYL-1,2,5-THIADIAZOLE
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3-Vinyl-1,2,5-thiadiazole is prepared by different methods: by one-pot reaction from 1,2,5-thiadiazole, by cyclization of 3,4-diamino-1-butene, and by the Wittig procedure either from 1,2,5-thiadiazolylmethylenetriphenylphosphorane or from 3-formyl-1,2,5-thiadiazole.Some physical and chemical properties are described.
- Bertini, V.,Lucchesini, F.,Munno, A. de
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- Method for preparing 1,2,3-thiadiazole-4-carboxylic acid
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The invention relates to a method for preparing 1,2,3-thiadiazole-4-carboxylic acid, which comprises: preparing 4,5-dicyano-1,2,3-thiadiazole by reaction between diaminomaleonitrile and dichloroethane; preparing 1,2,3-thiadiazole 4,5-dicarboxylic acid by the cyan-hydrolysis of 4,5-dicyano-1,2,3-thiadiazole; and preparing 1,2,3-thiadiazole-4-carboxylic acid by the decarboxylation reaction of 1,2,3-thiadiazole 4,5-dicarboxylic acid. The provided process route is high in synthesis rate of the target product, moreover, the process route can be magnified, the raw materials can be easily obtained and are cheap, and industrial production can be carried out.
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Paragraph 0019; 0026; 0027; 0028
(2017/04/22)
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- 4(SPIROPIPERIDINYL)METHYL SUBSTITUTED PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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3-Substituted pyrrolidines having a spiropiperidinylmethyl substituent on the 4-position of the ring are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.
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- 4-[(4-(CARBOXYETHYL) PIPERIDINYL) METHYL] PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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3-Substituted pyrrolidines having a 4-carboxypiperidinylmethyl substituent on the 4-position of the ring are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.
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Page 32-33; 25
(2010/02/07)
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- Preparation of 1,2,5-Thiadiazole-3-carboxaldehydes
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1,2,5-Thiadiazole-3-carboxaldehydes 1a-c were prepared by the acid-catalyzed decomposition of 3-azidomethyl-1,2,5-thiadiazoles 2a-c in 68-83percent yields, respectively.Pyrolysis of 2a and 2b afforded the imidazoles 4a and 4b in low yields.NBS-bromination of 1a and 1b gave the corresponding carboxylic acids 10a and 10b via acid bromides 9.Azides 2a and 2b gave the s-triazines 8a and 8b on treatment with NBS.
- Mataka, Shuntaro,Kurisu, Masayoshi,Takahashi, Kazufumi,Tashiro, Masashi
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p. 325 - 328
(2007/10/02)
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