13368-86-0

Basic information

• Product Name: 1,2,5-THIADIAZOLE-3-CARBOXYLIC ACID
• Synonyms: 1,2,5-THIADIAZOLE-3-CARBOXYLIC ACID;1,2,5-Thiadiazole-3-carboxylic acid≥ 99% (assay)
• CAS NO: 13368-86-0
• Molecular Formula: C₃H₂N₂O₂S
• Molecular Weight: 130.13
• Mol File: 13368-86-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 89℃
• Boiling Point: 292.8 °C at 760 mmHg
• Flash Point: 130.9 °C
• Appearance: /
• Density: 1.67g/cm³
• Vapor Pressure: 0.000817mmHg at 25°C
• Refractive Index: 1.631
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,2,5-THIADIAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,5-THIADIAZOLE-3-CARBOXYLIC ACID(13368-86-0)
• EPA Substance Registry System: 1,2,5-THIADIAZOLE-3-CARBOXYLIC ACID(13368-86-0)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 13368-86-0(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

InChI:InChI=1/C3H2N2O2S/c6-3(7)2-1-4-8-5-2/h1H,(H,6,7)

Upstream product

• 273-13-2 benzo[1,2,5]thiadiazole 
• 3762-94-5 1,2,5-thiadiazole-3,4-dicarboxylic acid 
• 75238-58-3 3-vinyl-1,2,5-thiadiazole 
• 515-94-6 2,3-diaminopropanoic acid 

Downstream Products

• 357926-22-8 (5S)-4-(4-fluorophenyl)-4-(6-fluoro-3-pyridyl)-5-methyl-2-(1,2,5-thiadiazol-3-yl)-2-imidazoline 
• 357927-27-6 2-fluoro-5-[(4S,5S)-4-(4-fluorophenyl)-5-methyl-2-(1,2,5-thiadiazol-3-yl)-4,5-dihydro-1H-imidazol-4-yl]pyridine 
• 152513-86-5 tert-butyl (1,2,5-thiadiazol-3-yl)carbamate 
• 30853-22-6 3-Chlorformyl-1,2,5-thiadiazol 

Relevant articles and documents

VINYL DERIVATIVES OF HETEROCYCLIC SYSTEMS AND THEIR POLIMERS: 3-VINYL-1,2,5-THIADIAZOLE

3-Vinyl-1,2,5-thiadiazole is prepared by different methods: by one-pot reaction from 1,2,5-thiadiazole, by cyclization of 3,4-diamino-1-butene, and by the Wittig procedure either from 1,2,5-thiadiazolylmethylenetriphenylphosphorane or from 3-formyl-1,2,5-thiadiazole.Some physical and chemical properties are described.

4-[(4-(CARBOXYETHYL) PIPERIDINYL) METHYL] PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

3-Substituted pyrrolidines having a 4-carboxypiperidinylmethyl substituent on the 4-position of the ring are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.

Preparation of 1,2,5-Thiadiazole-3-carboxaldehydes

1,2,5-Thiadiazole-3-carboxaldehydes 1a-c were prepared by the acid-catalyzed decomposition of 3-azidomethyl-1,2,5-thiadiazoles 2a-c in 68-83percent yields, respectively.Pyrolysis of 2a and 2b afforded the imidazoles 4a and 4b in low yields.NBS-bromination of 1a and 1b gave the corresponding carboxylic acids 10a and 10b via acid bromides 9.Azides 2a and 2b gave the s-triazines 8a and 8b on treatment with NBS.