Synthesis and preliminary data on new selective and potent gastric prokinetic substituted benzamides
A series of amino-halogen-N- benzamides was synthesized and evaluated for enhancing gastric emptying.Compared to metoclopramide, domperidone and bromopride, a number of compounds were shown to be more active in enhancing gastric motility (rat stomach emptying), devoid of dopaminergic D2-receptor antagonism (rat apomorphine test) and to be less toxic. substituted benzamides / gastrokinetic activity
Corona, L Del,Signorelli, G,Pinzetta, A,Coppi, G
p. 419 - 425
(2007/10/02)
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