151793-20-3Relevant articles and documents
Photoredox catalysis with aryl sulfonium salts enables site-selective late-stage fluorination
Li, Jiakun,Chen, Junting,Sang, Ruocheng,Ham, Won-Seok,Plutschack, Matthew B.,Berger, Florian,Chabbra, Sonia,Schnegg, Alexander,Genicot, Christophe,Ritter, Tobias
, p. 56 - 62 (2019/11/28)
Photoredox catalysis, especially in combination with transition metal catalysis, can produce redox states of transition metal catalysts to facilitate challenging bond formations that are not readily accessible in conventional redox catalysis. For arene functionalization, metallophotoredox catalysis has successfully made use of the same leaving groups as those valuable in conventional cross-coupling catalysis, such as bromide. Yet the redox potentials of common photoredox catalysts are not sufficient to reduce most aryl bromides, so synthetically useful aryl radicals are often not directly available. Therefore, the development of a distinct leaving group more appropriately matched in redox potential could enable new reactivity manifolds for metallophotoredox catalysis, especially if arylcopper(iii) complexes are accessible, from which the most challenging bond-forming reactions can occur. Here we show the conceptual advantages of aryl thianthrenium salts for metallophotoredox catalysis, and their utility in site-selective late-stage aromatic fluorination.
Compound and application thereof in cancer treatment
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Paragraph 0280-0282, (2019/05/28)
The invention provides a compound as shown in formula (I) or the pharmaceutically acceptable salt, stereoisomer, ether, ester, prodrug and solvate thereof. The compound can be used for preventing and/or treating cancer.
INHIBITORS OF THE MENIN-MLL INTERACTION
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Page/Page column 94-95, (2018/01/17)
The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.
Cu-Mediated C-H 18F-Fluorination of Electron-Rich (Hetero)arenes
McCammant, Matthew S.,Thompson, Stephen,Brooks, Allen F.,Krska, Shane W.,Scott, Peter J. H.,Sanford, Melanie S.
supporting information, p. 3939 - 3942 (2017/07/26)
This communication describes a method for the nucleophilic radiofluorination of electron-rich arenes. The reaction involves the initial C(sp2)-H functionalization of an electron-rich arene with MesI(OH)OTs to form a (mesityl)(aryl)iodonium salt
Leukotriene A4 hydrolase and cyclooxygense double target inhibitors and use thereof
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Paragraph 0051; 0052; 0053, (2016/10/07)
The invention discloses a double-target inhibitor for leukotriene A4 hydrolase and cyclooxygenase as well as a purpose of the double-target inhibitor. The double-target inhibitor is a compound shown in a general formula (I), wherein X1 and X2 are respectively and independently separated into hydrogen, halogen, alkyl or alkoxy; Y represents hydrogen, hydroxyl, halogen or alkyl; Z represents substituent groups at the fourth position and/or the fifth position of a benzoyl core benzene ring, and respectively represents hydrogen, halogen, amino, alkyl acylamino, alkyl substituted amino, trifluoromethyl or carboxyl alkyl acylamino; n is 2 to 4. The compound can be used for preparing medicine for treating, preventing or inhibiting inflammation such as arthritis and rheumatoid arthritis.
Synthesis and preliminary data on new selective and potent gastric prokinetic substituted benzamides
Corona, L Del,Signorelli, G,Pinzetta, A,Coppi, G
, p. 419 - 425 (2007/10/02)
A series of amino-halogen-N- benzamides was synthesized and evaluated for enhancing gastric emptying.Compared to metoclopramide, domperidone and bromopride, a number of compounds were shown to be more active in enhancing gastric motility (rat stomach emptying), devoid of dopaminergic D2-receptor antagonism (rat apomorphine test) and to be less toxic. substituted benzamides / gastrokinetic activity
