133863-87-3

Basic information

• Product Name: 2-METHOXY-6-(TRIFLUOROMETHYL)ANILINE
• Synonyms: 2-METHOXY-6-(TRIFLUOROMETHYL)ANILINE;2-methoxy-6-(trifloromethyl)aniline
• CAS NO: 133863-87-3
• Molecular Formula: C₈H₈F₃NO
• Molecular Weight: 191
• Mol File: 133863-87-3.mol

Chemical Properties

• Boiling Point: 221.9±40.0 °C(Predicted)
• Appearance: /
• Density: 1.280±0.06 g/cm3(Predicted)
• PKA: 1.40±0.10(Predicted)
• CAS DataBase Reference: 2-METHOXY-6-(TRIFLUOROMETHYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-6-(TRIFLUOROMETHYL)ANILINE(133863-87-3)
• EPA Substance Registry System: 2-METHOXY-6-(TRIFLUOROMETHYL)ANILINE(133863-87-3)

Safety Data

• Hazardous Substances Data: 133863-87-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Methoxy-6-(trifluoromethyl)aniline is used as a chemical intermediate for the synthesis of pharmaceuticals, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Methoxy-6-(trifluoromethyl)aniline is utilized as an intermediate in the production of agrochemicals, aiding in the creation of compounds that can enhance crop protection and yield.
Used in Dye and Pigment Industry:
2-Methoxy-6-(trifluoromethyl)aniline is employed as a key component in the synthesis of dyes and pigments, providing a range of color options for various applications, including textiles, plastics, and printing inks.
Used in Organic Compound Synthesis:
This aromatic amine is used as a building block in the synthesis of various organic compounds, expanding the scope of chemical research and development in multiple fields.
It is crucial to note that due to its toxic nature, 2-Methoxy-6-(trifluoromethyl)aniline must be handled with care to prevent ingestion, inhalation, or skin contact, and to minimize its impact on aquatic life and the environment.

Upstream product

• 454-90-0 3-(trifluoromethyl)anisole 
• 887144-94-7 Togni's reagent II 
• 90-04-0 2-methoxy-phenylamine 
• 386-72-1 2-nitro-3-(trifluoromethyl)phenol 

Downstream Products

• 147150-36-5 N-(2-Methoxy-6-(trifluoromethyl)phenyl)-5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide 
• 914635-64-6 2-bromo-1-methoxy-3-(trifluoromethyl)benzene 
• 1272528-82-1 3,4-diisopropoxy-5-(trifluoromethyl)benzoic acid 
• 1272528-81-0 3,4-dihydroxy-5-(trifluoromethyl)benzoic acid 
• 1272528-80-9 4-hydroxy-3-methoxy-5-(trifluoromethyl)benzoic acid 
• 116314-59-1 2-hydroxy-3-(trifluoromethyl)anisole 
• 116314-60-4 4-hydroxy-3-methoxy-5-(trifluoromethyl)benzaldehyde 

Relevant articles and documents

A practical synthesis of 2-methoxy-6-trifluoromethylaniline

A practical synthesis of 2-methoxy-6-trifluoromethylaniline is described via halogenation, nitration and reduction of 3-trifluoromethylanisole.

INHIBITING HUMAN INTEGRIN α4β7

Disclosed are small molecule antagonists of human α4β7 integrin, and methods of using them to treat a number of diseases and conditions.

Nickel-Catalyzed Direct C-H Trifluoromethylation of Free Anilines with Togni's Reagent

An efficient nickel-catalyzed C-H trifluoromethylation for the synthesis of trifluoromethylated free anilines using Togni's reagent has been developed. This approach exhibits a good functional group tolerance, good regioselectivity, and chemoselectivity under mild conditions. The newly developed economical one-step method is a better alternative to synthesize trifluoromethylated free anilines.

Preparation method of trifluoromethylamine

The invention relates to a preparation method of trifluoromethylamine. The method includes the following steps that aromatic amine shown in the formula (1) and a trifluoromethyl reagent shown in the formula (2) react in a solvent under the condition that an alkali and/or nickel compound exists, and the trifluoromethylamine compound shown in the formula (3) is generated. According to the preparation method of trifluoromethylamine, aromatic amine and 1-trifluoromethyl-1,2-iodobenzoyl-3(H)-ketone serve as raw materials and react under the condition that the alkali and/or nickel compound exists through the amino positioning effect on aromatic nucleus. The synthesis steps of the method are simple, the cost of the raw materials is low, the production cost of trifluoromethylamine can be greatly reduced, and large-scale industrialized production is promoted.

THERAPEUTIC ARYL-AM I DO-ARYL COMPOUNDS AND THEIR USE

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-amido-aryl compounds of the following formula (for convenience, collectively referred to herein as "AAA compounds"), which, inter alia, a

Substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides, compositions containing them, and their utility as herbicides

Novel substituted triazolo[1,5-a]pyrimidine-2-sulfonamides, e.g., 5,7-dimethyl-N-(2,6-dichlorophenyl)-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide and their agriculturally acceptable salts are prepared. These compounds and compositions containing them are useful for the control of unwanted vegetation. Novel substituted triazolo[1,5-a]pyrimidine-2-sulfonyl chlorides and substituted anilines and their use as intermediates are also described.