- Isoquine and Related Amodiaquine Analogues: A New Generation of Improved 4-Aminoquinoline Antimalarials
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Amodiaquine (AQ) (2) is a 4-aminoquinoline antimalarial that can cause adverse side effects including agranulocytosis and liver damage. The observed drug toxicity is believed to involve the formation of an electrophilic metabolite, amodiaquine quinoneimin
- O'Neill, Paul M.,Mukhtar, Amira,Stocks, Paul A.,Randle, Laura E.,Hindley, Stephen,Ward, Stephen A.,Storr, Richard C.,Bickley, Jamie F.,O'Neil, Ian A.,Maggs, James L.,Hughes, Ruth H.,Winstanley, Peter A.,Bray, Patrick G.,Park, B. Kevin
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p. 4933 - 4945
(2007/10/03)
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- Dye couplers
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The present invention concerns the aminophenols (I) as novel couplers STR1 wherein R1 and R2 may be the same or different and are hydrogen, alkyl and hydroxyalkyl of from 1 to about 6 carbons in the alkyl moiety, or R1 and R2 can also form, together with the nitrogen atom to which they are attached, a morpholine, piperidine or pyrrolidine ring, and R3 and R4 are hydrogen, alkyl, acyl and hydroxyalkyl having from 1 to about 6 carbons, and oxidative hair dye compositions containing same along with at least one primary dye intermediate in aqueous or hydroalcoholic media.
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- Organic synthesis
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The conversion of ortho-hydroxylated Mannich bases to the corresponding methylated compounds, e.g., cresols, can be effectively carried out using a novel hydrogenation technique.
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