- Synthesis of dimethoxy activated benzimidazoles and bisbenzimidazoles
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A range of 2-substituted-4,6-dimethoxy activated benzimidazoles and 2,2'-bisbenzimidazoles have been synthesized from 2-aminoanilide derivatives under acidic conditions. The starting materials were prepared either by acylation from 3,5-dimethoxyaniline followed by nitration, or by acylation from 3,5-dimethoxy-2-nitroaniline. The 2-nitroanilides were then reduced by palladium catalyzed reaction with hydrazine and subsequent acid catalyzed cyclization giving the corresponding 4,6-dimethoxybenzimidazoles and 4,6-dimethoxy-2,2'-bisbenzimidazoles. In addition, 2-phenyl-4,5,6-trimethoxybenzimidazole has been synthesized using a similar procedure.
- Alamgir, Mahiuddin,Black, David St C.,Bowyer, Paul K.,Condie, Glenn C.,Kumar, Naresh,Martinovic, Vesna,Sholihin, Hayat,Wood, Joanne
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p. 1189 - 1217
(2020/09/18)
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- Novel vitexin-inspired scaffold against leukemia
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Acute lymphoblastic leukemia (ALL) is the most common type of leukemia in children. Up to a quarter of ALL patients relapse and face poor prognosis. To identify new compound leads, we conducted a phenotypic screen using terrestrial natural product (NP) fr
- Ling, Taotao,Lang, Walter,Feng, Xiang,Das, Sourav,Maier, Julie,Jeffries, Cynthia,Shelat, Anang,Rivas, Fatima
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supporting information
p. 501 - 510
(2018/02/15)
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- Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties
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New resveratrol (RES) analogs were developed by replacing the aromatic 'core' of our initial naphthalene-based RES analogs with pseudo-heterocyclic (salicylaldoxime) or heterocyclic (benzofuran, quinoline, and benzothiazole) scaffolds. The resulting analo
- Bertini, Simone,Calderone, Vincenzo,Carboni, Isabella,Maffei, Roberta,Martelli, Alma,Martinelli, Adriano,Minutolo, Filippo,Rajabi, Mehdi,Testai, Lara,Tuccinardi, Tiziano,Ghidoni, Riccardo,MacChia, Marco
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experimental part
p. 6715 - 6724
(2010/10/19)
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- Alkoxy- and amidocarbonylation of functionalised aryl and heteroaryl halides catalysed by a Bedford palladacycle and dppf: A comparison with the primary Pd(II) precursors (PhCN)2PdCl2 and Pd(OAc) 2
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The versatility of a Bedford-type palladacycle 1, namely [{Pd(-Cl){κ2-P,C-P(OC6H2-2,4- tBu2)(OC6H3-2,4-tBu 2)2}}2], as a primary Pd source, in combination with the ligand bis-1,1′-(diphenylphosphino)ferrocene (dppf) has been established in carbonylation reactions of aryl and heteroaryl bromides with methanol, piperidine and related nucleophiles. Palladacycle 1 has been compared with other primary Pd sources, e.g. (PhCN)2PdCl2 and Pd(OAc)2. The efficacy of the carbonylation processes appear to be linked to the [Pd] concentration, substrate: catalyst ratio, CO pressure and reaction temperature. In amidocarbonylation, double carbonylation is observed for certain organohalides. In the case of 2,5-dibromopyridine, regioselective amination (Hartwig-Buchwald type) also occurs as a side-reaction. This journal is The Royal Society of Chemistry.
- Fairlamb, Ian J. S.,Grant, Stephanie,McCormack, Peter,Whittall, John
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p. 859 - 865
(2007/10/03)
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- A convenient method for the synthesis of 3,5,7-trimethoxy-2-phenyl-4-quinolones
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The synthesis of 2-aryl-3,5,7-trimethoxy-4-quinolones was accomplished in three steps starting from 3,5-dimethoxyaniline and an aroyl chloride. These structures might be used as potential flavonol analogs. (C) 2000 Elsevier Science Ltd.
- Beney,Hadjeri,Mariotte,Boumendjel
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p. 7037 - 7039
(2007/10/03)
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- Synthesis and Evaluation of Stilbene and Dihydrostilbene Derivatives as Potential Anticancer Agents That Inhibit Tubulin Polymerization
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An array of cis-, trans-, and dihydrostilbenes and some N-arylbenzylamines were synthesized and evaluated for their cytotoxicity in the five cancer cell cultures A-549 lung carcinoma, MCF-7 breast carcinoma, HT-29 colon adenocarcinoma, SKMEL-5 melanoma, a
- Cushman, Mark,Nagarathnam, Dhanapalan,Gopal, D.,Chakraborti, Asit K.,Lin, Chii M.,Hamel, Ernest
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p. 2579 - 2588
(2007/10/02)
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