134106-77-7

Basic information

• Product Name: methyl 8-(bromomethyl)-2-methyl-4-[(pyrrolidin-1-ylcarbonyl)oxy]-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3,6,7,8-tetrahydropyrrolo[3,2-e]indole-1-carboxylate
• Synonyms: Benzo(1,2-b:4,3-b')dipyrrole-1-carboxylic acid, 3,6,7,8-tetrahydro-8-(bromomethyl)-2-methyl-4-((1-pyrrolidinylcarbonyl)oxy)-6-((5,6,7-trimethoxy-1H-indol-2-yl)carbonyl)-, methyl ester
• CAS NO: 134106-77-7
• Molecular Formula: C₃₁H₃₃BrN₄O₈
• Molecular Weight: 669.5197
• Mol File: 134106-77-7.mol

Chemical Properties

• Boiling Point: 818.2°C at 760 mmHg
• Flash Point: 448.6°C
• Density: 1.503g/cm³
• Vapor Pressure: 7.26E-27mmHg at 25°C
• Refractive Index: 1.674
• CAS DataBase Reference: methyl 8-(bromomethyl)-2-methyl-4-[(pyrrolidin-1-ylcarbonyl)oxy]-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3,6,7,8-tetrahydropyrrolo[3,2-e]indole-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 8-(bromomethyl)-2-methyl-4-[(pyrrolidin-1-ylcarbonyl)oxy]-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3,6,7,8-tetrahydropyrrolo[3,2-e]indole-1-carboxylate(134106-77-7)
• EPA Substance Registry System: methyl 8-(bromomethyl)-2-methyl-4-[(pyrrolidin-1-ylcarbonyl)oxy]-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3,6,7,8-tetrahydropyrrolo[3,2-e]indole-1-carboxylate(134106-77-7)

Safety Data

• Hazardous Substances Data: 134106-77-7(Hazardous Substances Data)

Upstream product

• 123-75-1 pyrrolidine 
• 205652-14-8 (S)-8-Bromomethyl-4-hydroxy-2-methyl-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-1-carboxylic acid methyl ester 
• 177958-19-9 8-O-tert-butyldimethylsilyl-3-methoxycarbonyl-2-methylduocarmycin B₂ 
• 153925-97-4 3-methoxycarbonyl-2-methylduocarmycin A 

Relevant articles and documents

Synthesis and antitumor activity of duocarmycin derivatives: Modification of segment A of duocarmycin B2

Several A-ring pyrrole derivatives of duocarmycin B2 were synthesized effectively from the 3-hydroxy compounds by utilizing an interesting acid- catalyzed rearrangement, their anticellular activity was preliminarily evaluated by assays of growth inhibition of HeLa S3 cells (in vitro) and antitumor activity against murine sarcoma 180 (in vivo). The 8-O-N,N- dialkylcarbamoyl derivatives of the A-ring pyrrole compound showed remarkably potent in vivo antitumor activity, superior to that of duocarmycin B2. These derivatives were subjected to further biological evaluation. They exhibited potent antitumor activity toward murine solid tumors including M5076 sarcoma, B-16 melanoma and Colon 26 adenocarcinoma. Their most noteworthy feature was their efficacy against various human xenografts including LC-6 (lung), St-4 (stomach), and Co-3 (colon).