cas 134150-03-1, 4'-Bromo-4-(trifluoromethoxy)biphenyl

Articles about 134150-03-1Total 7 be found

Photocatalyzed Transition-Metal-Free Oxidative Cross-Coupling Reactions of Tetraorganoborates**
Readily accessible tetraorganoborate salts undergo selective coupling reactions under blue light irradiation in the presence of catalytic amounts of transition-metal-free acridinium photocatalysts to furnish unsymmetrical biaryls, heterobiaryls and arylated olefins. This represents an interesting conceptual approach to forge C?C bonds between aryl, heteroaryl and alkenyl groups under smooth photochemical conditions. Computational studies were conducted to investigate the mechanism of the transformation.
Music, Arif,Baumann, Andreas N.,Boser, Florian,Müller, Nicolas,Matz, Florian,Jagau, Thomas C.,Didier, Dorian
supporting information
p. 4322 - 4326
(2021/02/11)

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE
Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.
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Paragraph 00488; 00489; 00931; 00932

(2021/01/22)

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE
Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.
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Paragraph 00530; 00531; 00532; 00973; 009749; 00975

(2019/07/17)

C-Aryl glucoside SGLT2 inhibitors containing a biphenyl motif as potential anti-diabetic agents
A series of highly active C-aryl glucoside SGLT2 inhibitors containing a biphenyl motif were designed and synthesized for biological evaluation. Among the compounds tested, compound 16l demonstrated high inhibitory activity against SGLT2 (IC50 = 1.9 nM) with an excellent pharmacokinetic profile. Further study indicated that the in vivo efficacy of compound 16l was comparable to that of dapagliflozin, suggesting that further development would be worthwhile.
Ding, Yuyang,Mao, Liufeng,Xu, Dengfeng,Xie, Hui,Yang, Ling,Xu, Hongjiang,Geng, Wenjun,Gao, Yong,Xia, Chunguang,Zhang, Xiquan,Meng, Qingyi,Wu, Donghai,Zhao, Junling,Hu, Wenhui
supporting information
p. 2744 - 2748
(2015/06/08)

Liquid crystal compounds, liquid crystal medium and liquid crystal display
The instant invention relates to liquid crystal media comprising a strongly dielectrically positive component A, preferably comprising isothiocyanate compounds, most preferably compounds of formula I, as given in the text, and a further dielectrically positive component B, preferably comprising terminally polar substituted bi- or terphenyl compounds, most preferably comprising compounds of formula II, as given in the text, further to novel isothiocyanato compounds as well as to liquid crystal displays comprising these media, in particular to PDLC display and most particular to holographic PDLC displays. The instant invention further relates to compounds of formula I wherein the parameters are as as specified in the text.
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(2008/06/13)

A convenient synthesis of trifluoromethyl ethers by oxidative desulfurization-fluorination of dithiocarbonates
Trifluoromethyl ethers R-OCF3 are easily synthesized from the corresponding dithiocarbonates R-OCS2Me (R = aryl or primary alkyl) by a reagent system consisting of 70% HF/pyridine and an N-halo imide. When the reaction is applied to R-OCS2Me wherein R = secondary alkyl, tertiary alkyl, or benzylic group, fluorination leading to the corresponding alkyl fluorides R-F is achieved, whereas a combination of 50% HF/pyridine and N- bromosuccinimide affords the corresponding trifluoromethyl ethers R-OCF3 (R = secondary).
Kanie, Kiyoshi,Tanaka, Yoichiro,Suzuki, Kazundo,Kuroboshi, Manabu,Hiyama, Tamejiro
p. 471 - 484
(2007/10/03)

Cyclic hydrocarbon derivative and liquid crystal composition containing the same
A cyclic hydrocarbon derivative represented by formula (I): STR1 wherein each of Y1 and Y2 is independently F, Cl, CN, OCN, SCN, OCF3, OCF2 H, OCF2 CF3, CF3, R, --OR, --COOR or --OCOR, wherein R is alkyl, alkenyl or alkoxyalkyl, provided that at least one of Y1 and Y2 is R, --OR, --COOR or --OCOR; each of Z, Z1, Z2, Z3 and Z4 is independently a single bond, --CH2 CH2 --, --CH=CH--, --C C--, --COO--, --OCO--, --CH2 O--, OCH2 --, --(CH2)4 --, --(CH2)3 --O-- or --O--(CH2)3 --; ring A is group of formula (II): STR2 wherein each of X1, X2, X3, X4, X5, X6, X7, X8, X9, and X10 is independently H or D, provided that at least one of them is D; each of rings K, L, J, M and N is independently trans-1,4-cyclohexylene, 1,4-cyclohexenylene, substituted trans-1,4-cyclohexylene, 1,4-phenylene, substituted 1,4-phenylene, 1,3-dioxane-2,6-diyl, pyrimidine-2,5-diyl, pyridine-2,5-diyl, pyarazine-2,5-diyl or a group of formula (III): STR3 wherein each of X11, X12, X13, X14, X15, X16, X17, X18, X19, and X20 is independently H or D, provided that at least one of them is D; in which the ring of formula (III) may be the same as or different from ring A; and k, l, m, and n each independently is 0 or 1, provided that the sum of k, l, m, and n is 0, 1 or 2. The compound is useful as an electro-optic liquid crystal display material.
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(2008/06/13)