Characterization of the solution degradation products of histrelin, a gonadotropin releasing hormone (LH/RH) agonist
The degradation products of histrelin (1, Glu-His-Trp-Ser-Tyr-(D-N(im)-bzl-His)-Leu-Arg-Pro-NHEt) were determined in aqueous solution at pH 5.4 and 87°C over an 18-day period (47% degradation). These degradation products (2-5) resulted from the cleavage of Glu-His and Trp-Ser peptide bonds, His-Trp diketopiperazine formation, and racemization of serine and histidine residues.
Oyler,Naldi,Lloyd,Graden,Shaw,Cotter
p. 271 - 275
(2007/10/02)
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