134219-71-9

Basic information

• Product Name: 3-OXO-1-(PHENYLAMINO)-4,4,4-TRIFLUOROBUT-1-ENE
• Synonyms: (E)-4-ANILINO-1,1,1-TRIFLUORO-3-BUTEN-2-ONE;3-OXO-1-(PHENYLAMINO)-4,4,4-TRIFLUOROBUT-1-ENE;(3E)-1,1,1-trifluoro-4-(phenylamino)but-3-en-2-one
• CAS NO: 134219-71-9
• Molecular Formula: C₁₀H₈F₃NO
• Molecular Weight: 215.17
• Mol File: 134219-71-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-OXO-1-(PHENYLAMINO)-4,4,4-TRIFLUOROBUT-1-ENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-OXO-1-(PHENYLAMINO)-4,4,4-TRIFLUOROBUT-1-ENE(134219-71-9)
• EPA Substance Registry System: 3-OXO-1-(PHENYLAMINO)-4,4,4-TRIFLUOROBUT-1-ENE(134219-71-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 134219-71-9(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 202074-35-9 1,1,1-trifluoro-4-(phenylsulfonyl)but-3-ene-2,2-diol 
• 329915-02-8 1,1,1-trifluoro-4-(methylsulfonyl)but-3-ene-2,2-diol 
• 59938-06-6 4-ethoxy-1,1,1-trifluoro-3-butene-2-one 
• 120417-45-0 4-amino-1,1,1-trifluoro-3-buten-2-one 
• 910136-24-2 (E)-4-ethoxy-1,1,1-trifluorobut-3-en-2-one 
• 59938-06-6 (E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one 
• 21045-62-5 4-(diethylamino)-1,1,1-trifluorobut-3-en-2-one 

Downstream Products

• 1010796-61-8 2,2,2-trifluoro-N-phenyl-N-(4,4,4-trifluoro-3-oxobut-1-enyl)acetamide 
• 1010796-60-7 N-phenyl-N-(4,4,4-trifluoro-3-oxobut-1-enyl)oxalamic acid ethyl ester 
• 25199-77-3 4-(trifluoromethyl)quinoline 
• 347-42-2 2-trifluoromethyl-quinoline 

Relevant articles and documents

Synthesis of substituted 1-trifluoromethyl and 1-perfluoroalkyl-3- (arylamino)prop-2-en-1-one: Advances in the mechanism of Combes 2-trifluoromethyl and 2-perfluoroalkyl quinolines synthesis

We report a new synthesis and our study of the mechanism of formation of substituted 1-trifluoromethyl and 1-perfluoroalkyl-3-(phenylamino)prop-2-en-1- one starting from 3-(R-phenoxy)-3-perfluoroalkyl-prop-2-enals and arylamines. Reactivity study of the intermediates confirmed that 3-perfluoroalkyl-N, N′-diphenyl-1,5-diazapentadienes are the synthetic intermediates of the synthesis of 2-perfluoroalkylquinolines. The mechanism of the reaction of 1-trifluoromethyl and 1-perfluoroalkyl-3-(phenylamino)prop-2-en-1-one with POCl3 was studied. To our knowledge this is the first detection and isolation of N,N′-diaryldiazapentadiene derivatives as intermediates in the Combes F-alkyl substituted quinoline synthesis starting from enaminoketones. Finally, we succeeded isolating and identifying unsymmetrically substituted 2-perfluorolakyldiazapentadiene.

Bidentate and tetradentate β-aminovinyl trifluoromethylated ketones and their copper(II) complexes: Synthesis, characterization and redox chemistry

New polyfunctional bidentate and tetradentate trifluoromethylated enaminone ligands that bear redox-active and photosensitive moieties were synthesized in moderate to good yields and their coordination chemistry with copper(II) was examined. The crystal s

An ionic liquid as reaction medium for the synthesis of halo-containing β-enaminones at room temperature

A series of twenty halomethylated β-enaminones [RC(O)CH=C(R 1)NR 3 R 4, where R = CF3,CCl 3, CHCl2; R 1 = H, Me, Ph; R 3 = H, Me, Bu, Et; R 4 = Me, Et, Bu, allyl, tert-amyl, CH2CH 2OH, Bn, Ph] were synthesized using the ionic liquid [bmim]BF 4 at room temperature. It is demonstrated that this ionic liquid is a reaction medium suitable for the amination of β-alkoxyvinyl halomethyl ketones. The advantages of this method are the absence of solvents, short reaction times, and good yields.

A new method for the synthesis of CF3-containing aminovinyl ketones

A new method for the synthesis of aminovinyl trifluoroinethyl ketones was developed. The method is based on the reactions of 4-sulfonyl-1,1,1-trifluorobut-3-ene-2,2-diols with various alkyl-, aryl-, dialkyl-, and alkylarylamines. The stereochemistry of the compounds obtained was studied.

Regioselective synthesis of trifluoromethyl substituted quinolines from trifluoroacetyl acetylenes

Trifluoromethyl substituted quinolines have been prepared by 1,2- or 1,4-addition of anilines to trifluoroacetyl acetylenes followed by intramolecular acid catalyzed ring closure.

O-N, S-N AND N-N EXCHANGE REACTIONS AT OLEFINIC CARBON ATOMS: FACILE SYNTHETIC METHOD FOR β-TRIFLUOROACETYLVINYLAMINES

β-Trifluoroacetylvinyl ethers 1 and sulfides 2 react easily with various amines at room temperature to give β-trifluoroacetylvinylamines 3 in excellent yields.This O-N and S-N exchange reaction can be extended to N-N exchange reaction.