25199-77-3

Basic information

• Product Name: 4-(TRIFLUOROMETHYL)QUINOLINE
• Synonyms: 4-(TRIFLUOROMETHYL)QUINOLINE
• CAS NO: 25199-77-3
• Molecular Formula: C10H6F3N
• Molecular Weight: 197.16
• Mol File: 25199-77-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 135-137 °C(Press: 23 Torr)
• Appearance: /
• Density: 1.364 g/cm3
• PKA: 2.56±0.13(Predicted)
• CAS DataBase Reference: 4-(TRIFLUOROMETHYL)QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TRIFLUOROMETHYL)QUINOLINE(25199-77-3)
• EPA Substance Registry System: 4-(TRIFLUOROMETHYL)QUINOLINE(25199-77-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 25199-77-3(Hazardous Substances Data)

Usage

General Description

4-(Trifluoromethyl)quinoline is a chemical compound with the molecular formula C10H6F3N. It is a quinoline derivative that is characterized by the presence of a trifluoromethyl group attached to the fourth position of the quinoline ring. 4-(TRIFLUOROMETHYL)QUINOLINE is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals due to its versatile reactivity and structural features. Its unique properties make it a valuable intermediate in the production of various organic compounds. Additionally, 4-(Trifluoromethyl)quinoline has been studied for its potential applications in medicinal chemistry, particularly as a scaffold for the development of bioactive molecules with diverse pharmacological activities.

Upstream product

• 142503-36-4 1,1,1,5,5,5-Hexafluoro-3-phenylaminomethylene-pentane-2,4-dione 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 3964-04-3 4-bromoquinoline 
• 1895006-01-5 dimesityl(trifluoromethyl)sulfonium trifluoromethanesulfonate 
• 91-22-5 quinoline 
• 2806-29-3 2-chloro-4-(trifluoromethyl)quinoline 
• 62-53-3 aniline 
• 25199-84-2 4-(trifluoromethyl)quinolin-2(1H)-one 
• 590372-17-1 2-bromo-4-(trifluoromethyl)quinoline 
• 155495-61-7 2,2,2-Trifluoro-1-(4-trifluoromethyl-quinolin-3-yl)-ethanone 
• 134219-71-9 1-trifluoromethyl-3-(phenylamino)prop-2-en-1-one 

Downstream Products

• 155495-82-2 4-trifluoromethyl-3-quinolinecarboxylic acid 

Relevant articles and documents

Metallaphotoredox Perfluoroalkylation of Organobromides

Ruppert-Prakash type reagents (TMSCF3, TMSC2F5, and TMSC3F7) are readily available, air-stable, and easy-to-handle fluoroalkyl sources. Herein, we describe a mild, copper-catalyzed cross-coupling of these fluoroalkyl nucleophiles with aryl and alkyl bromides to produce a diverse array of trifluoromethyl, pentafluoroethyl, and heptafluoropropyl adducts. This light-mediated transformation proceeds via a silyl-radical-mediated halogen atom abstraction pathway, which enables perfluoroalkylation of a broad range of organobromides of variable steric and electronic demand. The utility of the method is demonstrated through the late-stage functionalization of several drug analogues.

Borazine-CF3? Adducts for Rapid, Room Temperature, and Broad Scope Trifluoromethylation

A fluoroform-derived borazine CF3? transfer reagent is used to effect rapid nucleophilic reactions in the absence of additives, within minutes at 25 °C. Inorganic electrophiles spanning seven groups of the periodic table can be trifluoromethylated in high yield, including transition metals used for catalytic trifluoromethylation. Organic electrophiles included (hetero)arenes, enabling C?H and C?X trifluoromethylation reactions. Mechanistic analysis supports a dissociative mechanism for CF3? transfer, and cation modification afforded a reagent with enhanced stability.

Novel Sulfonaminoquinoline Hepcidin Antagonists

The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.