134336-96-2Relevant articles and documents
Novel Nonopioid Non-Antiinflammatory Analgesics: 3-(Aminoalkyl)- and 3-oxazolopyridin-2(3H)-ones
Flouzat, Christine,Bresson, Yvette,Mattio, Anny,Bonnet, Jacqueline,Guillaumet, Gerald
, p. 497 - 503 (2007/10/02)
A series of 3-(aminoalkyl)- and 3-oxazolopyridin-2(3H)-ones were prepared from their respective oxazolopyridin-2(3H)-ones. Several members of this group were found to possess potent analgesic activity in the mouse during a p-phenylquinone writhing induced test. Among them, phenylpiperazine compounds with two-carbon length alkyl chains, 2a and 2b, appeared by high analgesic with little toxicity having neither an antiinflammatory effect nor opioid receptor affinity. The synthesis and structure-affinity relationships for this series are detailed.
Oxazolopyridine compounds
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, (2008/06/13)
Compounds of general formula (I): STR1 in which: R1 and R2 each represent a hydrogen atom or, with the oxygen and nitrogen, form an --O--CO--N-- linkage, W represents a halogen atom or a lower alkyl or alkoxy group optionally substituted with one or more halogen atoms, such as trifluoromethyl, and m being between 0 and 3, A represents a linear or branched lower alkylene group, and Ar represents an aryl or heteroaryl group optionally substituted with one or more halogen atoms or with one or more lower alkyl, hydroxy, hydroxysulfonyloxy, lower alkoxy or aryloxy groups optionally substituted with one or more halogen atoms, such as a trifluoromethyl group, on the understanding that lower alkyl or lower alkyloxy radical is understood to mean a linear or branched alkyl group comprising from 1 to 6 carbon atom, their isomers, epimers and diastereoisomers. Medicinal products useful in the treatment of pain.
